New Research

Sept. 23, 2018

Research Paper of the Month

We know that air pollution affects the heart and blood vessels through multiple mechanisms.  Heart attacks causing sudden death is the signature outcome of air pollution exposure.  However it was indeed sobering to see this study of almost 4,000 people that showed even in middle aged adults that didn’t have known heart disease, air pollution exposure well below the EPA standards, increased the size of heart chambers, which is indicative of impaired function, and a prelude to heart failure.  Extrapolating from this study to the Wasatch Front suggests that our air pollution is responsible for about a 10% increase in the size of our heart chambers.

Aung N, et al. Association Between Ambient Air Pollution and Cardiac Morpho-Functional Phenotypes, insights From the UK Biobank Population Imaging Study. Originally published3 Aug 2018Circulation. 2018;0:CIRCULATIONAHA.118.034856

Resting heart rate is often thought of as a marker, although not a perfect one, of physical fitness.  Air pollution is associated with a higher resting heart rate.

Xie X, et al. Long-term exposure to fine particulate matter and tachycardia and heart rate: Results from 10 million reproductive-age adults in China. Environ Pollut. 2018 Aug 11;242(Pt B):1371-1378. doi: 10.1016/j.envpol.2018.08.022. [Epub ahead of print]

More evidence that air pollution is associated with a worse blood lipid profile.

Yang BY, et al. Exposure to ambient air pollution and blood lipids in adults: The 33 Communities Chinese Health Study. Environ Int. 2018 Jul 23;119:485-492. doi: 10.1016/j.envint.2018.07.016. [Epub ahead of print]

Another study showing that air pollution harms brain development in children, in this case through chemical changes in DNA.

Peng C, et al. Residential Proximity to Major Roadways at Birth, DNA Methylation at Birth and Midchildhood, and Childhood Cognitive Test Scores: Project Viva(Massachusetts, USA) Published: 18 September 2018, DOI: https://doi.org/10.1289/EHP2034

Air pollution is associated with increased rates of upper and lower respiratory and ear infections in children.

Kennedy CM, et al. Associations of mobile source air pollution during the first year of life with childhood pneumonia, bronchiolitis, and otitis media. Environ Epidemiol. 2018 Mar;2(1). pii: e007. doi: 10.1097/EE9.0000000000000007.

Multiple new studies showing air pollution causing adverse pregnancy outcomes, including closer proximity to industrial pollution sources associated with low birth weight newborns.

Gong X et al. Associations between maternal residential proximity to air emissions from industrial facilities and low birth weight in Texas, USA. Environ Int. 2018 Aug 7;120:181-198. doi: 10.1016/j.envint.2018.07.045. [Epub ahead of print]

Wang L, et al. Association between early prenatal exposure to ambient air pollution and birth defects: evidence from newborns in Xi’an, China. J Public Health (Oxf). 2018 Aug 18. doi: 10.1093/pubmed/fdy137. [Epub ahead of print]

He T, et al. Ambient air pollution, H19/DMR methylation in cord blood and newborn size: A pilot study in Zhengzhou City, China. Chemosphere. 2018 Aug 30;212:863-871. doi: 10.1016/j.chemosphere.2018.08.140. [Epub ahead of print]

Barn P, et al. The effect of portable HEPA filter air cleaner use during pregnancy on fetal growth: The UGAAR randomized controlled trial. Environ Int. 2018 Sep 10. pii: S0160-4120(18)31141-3. doi: 10.1016/j.envint.2018.08.036. [Epub ahead of print]

Wang Q, et al. Identifying windows of susceptibility for maternal exposure to ambient air pollution and preterm birth. Environ Int. 2018 Sep 18;121(Pt 1):317-324. doi: 10.1016/j.envint.2018.09.021. [Epub ahead of print]

Liu WY, et al. Association between ambient air pollutants and preterm birth in Ningbo, China: a time-series study. BMC Pediatr. 2018 Sep 20;18(1):305. doi: 10.1186/s12887-018-1282-9.

More evidence that air pollution causes DNA damage and increases DNA repair activity.

Ledda C, et al. Mutagenic and DNA repair activity in traffic policemen: a case-crossover study.J Occup Med Toxicol. 2018 Aug 8;13:24. doi: 10.1186/s12995-018-0206-9. eCollection 2018.

A meta-analysis of studies showing air pollution causes shorter telomere length, a marker of accelerated aging, and predictor of premature death.

Zhao B, et al. Air pollution and telomere length: a systematic review of 12,058 subjects. Cardiovasc Diagn Ther. 2018 Aug;8(4):480-492. doi: 10.21037/cdt.2018.06.05.

Air pollution during pregnancy is associated with increased rates of obesity in childhood.

Kim JS, et al. Longitudinal associations of in utero and early life near-roadway air pollution with trajectories of childhood body mass index. Environ Health. 2018 Sep 14;17(1):64. doi: 10.1186/s12940-018-0409-7.

Several new studies showing air pollution’s association with increased risk of cancer–childhood cancers, lung cancer, and cancers of the upper digestive tract and stomach.

Consonni D, et al. Outdoor particulate matter (PM10) exposure and lung cancer risk in the EAGLE study. PLoS One. 2018 Sep 14;13(9):e0203539. doi: 10.1371/journal.pone.0203539. eCollection 2018.

Weinmayr G, et al. Particulate matter air pollution components and incidence of cancers of the stomach and the upper aerodigestive tract in the European Study of Cohorts of Air Pollution Effects (ESCAPE). Environ Int. 2018 Aug 7;120:163-171. doi: 10.1016/j.envint.2018.07.030. [Epub ahead of print]

Ribeiro AG, et al. Incidence and mortality risk for respiratory tract cancer in the city of São Paulo, Brazil: Bayesian analysis of the association with traffic density. Cancer Epidemiol. 2018 Jul 23;56:53-59. doi: 10.1016/j.canep.2018.07.005. [Epub ahead of print]

Seifi M, et al. Exposure to ambient air pollution and risk of childhood cancers: A population-based study in Tehran, Iran. Sci Total Environ. 2018 Jul 24;646:105-110. doi: 10.1016/j.scitotenv.2018.07.219. [Epub ahead of print]

Two new studies showing increased rates of appendicitis with more air pollution.

Aroui H, et al. The effect of environmental factors on the incidence of perforated appendicitis. Ann Ital Chir. 2018 Jul 23;7. pii: S0003469X18028014. [Epub ahead of print]

Chen CC, et al. Effects of ambient air pollution exposure on frequency of hospital admissions for appendicitis in Taipei, Taiwan.J Toxicol Environ Health A. 2018 Jul 26:1-7. doi:10.1080/15287394.2018.1498276. [Epub ahead of print]

Babies born to mothers living near fracking operations are more likely to born prematurely, have low birth weight, and worse APGAR scores.  Fracking chemicals are toxic to fetal development.

Shale gas development and infant health: Evidence from Pennsylvania.J Health Econ. 2018 Aug 13;61:134-150. doi: 10.1016/j.jhealeco.2018.07.004. [Epub ahead of print]

Infant mortality increases with air pollution.  This study from Africa shows about the same relationship between infant mortality and air pollution, and adult mortality–a 1% increase for every 1 ug/m3 in PM2.5, or about 22% of infant deaths.

Heft-Neal S. et al. Robust relationship between air quality and infant mortality in AfricaNature volume 559, pages254–258 (2018)

 

Research Paper of the Month

Research continues to build that air pollution is associated with a broad range of neurologic diseases.  This study breaks new ground in finding a connection between air pollution and Amyotrophic Lateral Sclerosis (ALS), i.e. Lou Gehrig’s disease.

Povedano M, et al. Spatial Assessment of the Association between Long-Term Exposure to Environmental Factors and the Occurrence of Amyotrophic Lateral Sclerosis in Catalonia, Spain: A Population-Based Nested Case-Control Study.  Neuroepidemiology. 2018 May 31;51(1-2):33-49. doi: 10.1159/000489664. [Epub ahead of print]

New and more detailed information about how air pollution damages the lungs.  It actually causes a loss of the number of minute air sacs (alveoli) in the lungs when exposure occurs during prenatal or early post natal life.

Lopes dB, et al.  Pre- and postnatal exposure of mice to concentrated urban PM2.5 decreases the number of alveoli and leads to altered lung function at an early stage of life.  Environ Pollut. 2018 Jun 4;241:511-520. doi: 10.1016/j.envpol.2018.05.055. [Epub ahead of print]

More evidence that air pollution causes pregnancy complications like pre-term births, hypertension of pregnancy, and the most severe complications–miscarriage and still births.

Li X, et al. Analysis of short-term and sub-chronic effects of ambient air pollution on preterm birth in central China.  Environ Sci Pollut Res Int. 2018 May 2. doi: 10.1007/s11356-018-2061-8. [Epub ahead of print]

Casey JA, et al. Coal and oil power plant retirements in California associated with reduced preterm birth among populations nearby. American Journal of Epidemiology, kwy110, https://doi.org/10.1093/aje/kwy110  Published: 16 May 2018

Xue T, et al. Association Between Hypertensive Disorders in Pregnancy and Particulate Matter in the Contiguous United States, 1999-2004. Hypertension. 2018 May 21. pii: HYPERTENSIONAHA.118.11080. doi: 10.1161/HYPERTENSIONAHA.118.11080. [Epub ahead of print].

Grippo A, et al. Air pollution exposure during pregnancy and spontaneous abortion and stillbirth. Rev Environ Health. 2018 Jul 5. pii: /j/reveh.ahead-of-print/reveh-2017-0033/reveh-2017-0033.xml. doi: 10.1515/reveh-2017-0033. [Epub ahead of print]

Another study showing that air pollution changes the chemical environment of placental DNA, increasing the vulnerability of the unborn to chronic disease later in life.

Maghbooli Z, et al. Air pollution during pregnancy and placental adaptation in the levels of global DNA methylation.  PLoS One. 2018 Jul 6;13(7):e0199772. doi: 10.1371/journal.pone.0199772. eCollection 2018.

Another study showing that decreased pollution improved fertility rates.

Casey JA, et al. Increase in fertility following coal and oil power plant retirements in California.  Environ Health. 2018 May 2;17(1):44. doi: 10.1186/s12940-018-0388-8.

We are learning more and more about how air pollution may contribute to inflammatory bowel diseases.   This study in mice shows that air pollution disrupts the components of bowel bacteria, leaving the bowel more vulnerable to inflammation.

Mutlu EA, et al. Inhalational exposure to particulate matter air pollution alters the composition of the gut microbiome.  Environ Pollut. 2018 May 18;240:817-830. doi: 10.1016/j.envpol.2018.04.130. [Epub ahead of print]

More epidemiologic evidence of air pollution increasing the risks for strokes and dementia

Béjot Y, et al. A review of epidemiological research on stroke and dementia and exposure to air pollution.  Int J Stroke. 2018 Jan 1:1747493018772800. doi: 10.1177/1747493018772800. [Epub ahead of print]

Another study that suggests a connection between air pollution and brain cancer, and this one reveals a likely mechanism.

Ljubimova, JY, et al. Coarse particulate matter (PM2.5–10) in Los Angeles Basin air induces expression of inflammation and cancer biomarkers in rat brains. Scientific Reports, 2018; 8 (1) DOI: 10.1038/s41598-018-23885-3

This review article shows more evidence for the connection between air pollution and mental disorders, especially depression.

Buoli M, et al. Is there a link between air pollution and mental disorders?
Environ Int. 2018 Jun 4;118:154-168. doi: 10.1016/j.envint.2018.05.044. [Epub ahead of print]

More studies showing a significant connection between air pollution and suicide, substance abuse, and schizophrenia.

Lee H, et al. Ambient air pollution and completed suicide in 26 South Korean cities: Effect modification by demographic and socioeconomic factors. Sci Total Environ. 2018 Oct 15;639:944-951. doi: 10.1016/j.scitotenv.2018.05.210. Epub 2018 May 26.

Szyszkowicz M, et al. Ambient air pollution exposure and emergency department visits for substance abuse.  PLoS One. 2018 Jun 29;13(6):e0199826. doi: 10.1371/journal.pone.0199826. eCollection 2018.

Duan J, et al. Is the serious ambient air pollution associated with increased admissions for schizophrenia?  Sci Total Environ. 2018 Jul 2;644:14-19. doi: 10.1016/j.scitotenv.2018.06.218. [Epub ahead of print]

Another study showing that air pollution increases the incidence of infections in general, in this case, ear infections.

Park M, et al. Air pollution influences the incidence of otitis media in children: A national population-based study.  PLoS One. 2018 Jun 28;13(6):e0199296. doi: 10.1371/journal.pone.0199296. eCollection 2018.

More evidence that air pollution impairs lung function in children.

Finke I, et al. Air pollution and airway resistance at age 8 years – the PIAMA birth cohort study.  Environ Health. 2018 Jul 17;17(1):61. doi: 10.1186/s12940-018-0407-9.

We are often asked how bad does the air pollution have to get to make it more dangerous to your health than the benefits of the exercise itself?  We still don’t really know the answer, but this study suggests that with dirty air, the benefits of the exercise are wiped out after 15 minutes, and that after 75 minutes, the air pollution is doing more damage than the benefits of the exercise.

Pasqua LA, et al. Exercising in Air Pollution: The Cleanest versus Dirtiest Cities Challenge.
Int J Environ Res Public Health. 2018 Jul 17;15(7). pii: E1502. doi: 10.3390/ijerph15071502.

This study suggests that breathing through tightly fitting N-95 masks reduces the amount of particles inhaled, but doesn’t decrease the body inflammation at the microscopic level, and therefore the health consequences of pollution.

More evidence that air pollution increases the risk of stomach cancer, and other cancers of the upper GI tract.

Nagel G, et al. Air pollution and incidence of cancers of the stomach and the upper aerodigestive tract in the European Study of Cohorts for Air Pollution Effects (ESCAPE). Int J Cancer. 2018 Apr 26. doi: 10.1002/ijc.31564. [Epub ahead of print]

 

April 27, 2018

Research Paper of the Month

We have become increasingly alarmed at the body of research showing how harmful air pollution is to the brain, including the presence of air pollution particles penetrating brain tissue itself.

The latest research examined the brains of 203 people, ranging in age from less than one year old to 40 years old. At autopsy (causes of death were usually trauma), every single brain but one showed the abnormal proteins that are the microbiologic hallmarks of Alzheimer’s, even in an 11 month old. And the amount of these abnormal proteins was proportional to the amount of air pollution where the subjects lived. The principle author, probably the world’s expert on this type of research said,
“Alzheimer’s disease hallmarks start in childhood in polluted environments, and we must implement effective preventative measures early. It is useless to take reactive actions decades later.”

Calderón-Garcidueñas L, et al.  Hallmarks of Alzheimer disease are evolving relentlessly in Metropolitan Mexico City infants, children and young adults. APOE4 carriers have higher suicide risk and higher odds of reaching NFT stage V at ≤ 40 years of age. Environmental Research, 2018; 164: 475 DOI: 10.1016/j.envres.2018.03.023

This study was done evaluating a large patient population of over 100,000 right here on Utah’s Wasatch Front.  It showed that serious lower respiratory infections in every age group, were increased with more air pollution, even short term exposure lasting only several days.

Horne BD, et al. Short-term Elevation of Fine Particulate Matter Air Pollution and Acute Lower Respiratory Infection. Am J Respir Crit Care Med. 2018 Apr 13. doi: 10.1164/rccm.201709-1883OC. [Epub ahead of print]

More evidence connecting air pollution to obesity, diabetes, and metabolic syndrome

Matthiessen C, et al. Long-term exposure to airborne particulate matter and NO2 and prevalent and incident metabolic syndrome – Results from the Heinz Nixdorf Recall Study. Environ Int. 2018 Apr 10;116:74-82. doi: 10.1016/j.envint.2018.02.035. [Epub ahead of print]

Yang BY, et al. Ambient air pollution in relation to diabetes and glucose-homoeostasis markers in China: a cross-sectional study with findings from the 33 Communities Chinese Health Study.  Lancet Planet Health. 2018 Feb;2(2):e64-e73. doi: 10.1016/S2542-5196(18)30001-9. Epub 2018 Feb 9.

Lucht SA, et al. Air Pollution and Glucose Metabolism: An Analysis in Non-Diabetic Participants of the Heinz Nixdorf Recall Study. Environ Health Perspect. 2018 Apr 3;126(4):047001. doi: 10.1289/EHP2561.

Wang M, et al. Association between Short-Term Exposure to Air Pollution and Dyslipidemias among Type 2 Diabetic Patients in Northwest China: A Population-Based Study. Int J Environ Res Public Health. 2018 Mar 30;15(4). pii: E631. doi: 10.3390/ijerph15040631.

This study demonstrated with one mechanism of air pollution’s effect on the lungs is the triggering of cell death in the lining of the airways.

Xu F, et al. Necroptosis Contributes to Urban Particulate Matter-Induced Airway Epithelial Injury.  Cell Physiol Biochem. 2018 Mar 29;46(2):699-712. doi: 10.1159/000488726. [Epub ahead of print]

More evidence that air pollution changes the functioning of genes, one mechanism by which it provokes diseases of the heart, lungs, and endocrine systems.

Favé M-J, et al. Gene-by-environment interactions in urban populations modulate risk phenotypes. Nature Communications, 2018; 9 (1) DOI: 10.1038/s41467-018-03202-2

Plusquin M, et al. DNA methylome marks of exposure to particulate matter at three time points in early life.  Environ Sci Technol. 2018 Mar 30. doi: 10.1021/acs.est.7b06447. [Epub ahead of print]

Jie Y, et al. Changes in gene expression in lungs of mice exposed to traffic-related air pollution.  Mol Cell Probes. 2018 Apr 2. pii: S0890-8508(18)30034-3. doi: 10.1016/j.mcp.2018.03.005. [Epub ahead of print].

Domingues ÉP, et al. Genotoxic effects following exposure to air pollution in street vendors from a high-traffic urban area. Environ Monit Assess. 2018 Mar 14;190(4):215. doi: 10.1007/s10661-018-6598-2.

Krauskopf J, Caiment F, van Veldhoven K, Chadeau-Hyam M, Sinharay R, Chung KF, Cullinan P, Collins P, Barratt B, Kelly FJ, Vermeulen R, Vineis P, de Kok TM, Kleinjans JC. The human circulating miRNome reflects multiple organ disease risks in association with short-term exposure to traffic-related air pollution. Environ Int. 2018 Jan 27;113:26-34. doi: 10.1016/j.envint.2018.01.014. [Epub ahead of print] PMID: 29421404 [PubMed – as supplied by publisher]

More evidence connecting air pollution to autism

Kalkbrenner A, et al. Air Toxics in Relation to Autism Diagnosis, Phenotype, and Severity in a U.S. Family-Based Study. Environ Health Perspect; DOI:10.1289/EHP1867

People living near oil and gas drilling operations have a higher incidence of preterm birth.

Whitworth KW, et al. Drilling and Production Activity Related to Unconventional Gas Development and Severity of Preterm Birth. Environ Health Perspect; DOI:10.1289/EHP2622

Lead is usually thought of only as a neurotoxin, with focus primarily on what it does to the brain development of children.  But lead exposure is also associated with a higher mortality rate among adults, contributing to over 400,000 deaths a year from heart disease.

Lanphear B, et al. Low-level lead exposure and mortality in US adults: a population-based cohort study. The Lancet Public Health, 2018 DOI: 10.1016/S2468-2667(18)30025-2

More evidence that air pollution contributes to the risk of strokes

Kulick ER, et al. Residential Proximity to Major Roadways and Risk of Incident Ischemic Stroke in NOMAS (The Northern Manhattan Study). Stroke. 2018 Mar 14. pii: STROKEAHA.117.019580. doi: 10.1161/STROKEAHA.117.019580. [Epub ahead of print]

Black Americans suffer higher cardiovascular risk from air pollution than do caucasians.

Erqou S, et al. Particulate Matter Air Pollution and Racial Differences in Cardiovascular Disease Risk. Arterioscler Thromb Vasc Biol. 2018 Mar 15. pii: ATVBAHA.117.310305. doi: 10.1161/ATVBAHA.117.310305. [Epub ahead of print]

More evidence that air pollution causes an increase risk for the pregnancy complication known as preeclampsia.

Wang Q, et al. Effects of prenatal exposure to air pollution on preeclampsia in Shenzhen, China.  Environ Pollut. 2018 Feb 18;237:18-27. doi: 10.1016/j.envpol.2018.02.010. [Epub ahead of print]

More air pollution exposure is associated with smaller volumes of brain grey matter.

Power MC, et al.  The Association of Long-Term Exposure to Particulate Matter Air Pollution with Brain MRI Findings: The ARIC Study.  Environ Health Perspect. 2018 Feb 16;126(2):027009. doi: 10.1289/EHP2152.

This is another study showing increased risk for congenital heart defects with more air pollution.

Ren Z, et al. Maternal exposure to ambient PM10 during pregnancy increases the risk of congenital heart defects: Evidence from machine learning models. Sci Total Environ. 2018 Feb 19;630:1-10. doi: 10.1016/j.scitotenv.2018.02.181. [Epub ahead of print]

More evidence that air pollution increases blood pressure and arterial stiffness, and one of these studies showed that radioactive pollution particles also increased blood pressure.

Baumgartner J, et al. Household air pollution and measures of blood pressure, arterial stiffness and central haemodynamics. Heart. 2018 Feb 9. pii: heartjnl-2017-312595. doi: 10.1136/heartjnl-2017-312595. [Epub ahead of print]

Nyhan MM, et al. Associations Between Ambient Particle Radioactivity and Blood Pressure: The NAS (Normative Aging Study). J Am Heart Assoc. 2018 Mar 15;7(6). pii: e008245. doi: 10.1161/JAHA.117.008245.

Salameh P, et al. Hypertension prevalence and living conditions related to air pollution: results of a national epidemiological study in Lebanon. Environ Sci Pollut Res Int. 2018 Feb 13. doi: 10.1007/s11356-018-1411-x. [Epub ahead of print]

Some of the increased risk for heart attack maybe related to the rate of rise in air pollution.  In other words, a rapid rise in pollution may have more of an impact than the eventual pollution concentration itself.

Rasche M, et al. Rapid increases in nitrogen oxides are associated with acute myocardial infarction: A case-crossover study. Eur J Prev Cardiol. 2018 Jan 1:2047487318755804. doi: 10.1177/2047487318755804. [Epub ahead of print]

Air pollution causes increased fragmentation of human sperm.

Bosco L, et al. Sperm DNA fragmentation: An early and reliable marker of air pollution.
Environ Toxicol Pharmacol. 2018 Feb 7;58:243-249. doi: 10.1016/j.etap.2018.02.001. [Epub ahead of print]

Here’s one we wouldn’t have thought of.  We know air pollution affects brain function, including increasing depression, suicidal tendencies, and impairing cognition.  This study shows that air pollution is associated with criminal activity and unethical behavior.

Lu J, et al. Polluted Morality: Air Pollution Predicts Criminal Activity and Unethical Behavior. Psychological Science, 2018; 095679761773580 DOI: 10.1177/0956797617735807

Air pollution exposure during pregnancy increases the risk of asthma after birth during childhood.

Lavigne É, Bélair MA, Rodriguez Duque D, Do MT, Stieb DM, Hystad P, van Donkelaar A, Martin RV, Crouse DL, Crighton E, Chen H, Burnett RT, Weichenthal S, Villeneuve PJ, To T, Brook JR, Johnson M, Cakmak S, Yasseen AS 3rd, Walker M. Effect modification of perinatal exposure to air pollution and childhood asthma incidence. Eur Respir J. 2018 Feb 1. pii: 1701884. doi: 10.1183/13993003.01884-2017.

Another study showing increased rates of death with short term air pollution.

Huang J, Pan X, Guo X, Li G. Impacts of air pollution wave on years of life lost: A crucial way to communicate the health risks of air pollution to the public. Environ Int. 2018 Jan 29;113:42-49. doi: 10.1016/j.envint.2018.01.022. [Epub ahead of print] PMID: 29421406 [PubMed – as supplied by publisher]

The association between air pollution and still births continue to mount.

Yang S, Tan Y, Mei H, Wang F, Li N, Zhao J, Zhang Y, Qian Z, Chang JJ, Syberg KM, Peng A, Mei H, Zhang D, Zhang Y, Xu S, Li Y, Zheng T, Zhang B. Ambient air pollution the risk of stillbirth: A prospective birth cohort study in Wuhan, China. Int J Hyg Environ Health. 2018 Feb 5. pii: S1438-4639(17)30531-X. doi: 10.1016/j.ijheh.2018.01.014. [Epub ahead of print] PMID: 29422441 [PubMed – as supplied by publisher]

Air pollution is associated relapses in multiple sclerosis

Jeanjean M, Bind MA, Roux J, Ongagna JC, de Sèze J, Bard D, Leray E. Ozone, NO<sub>2</sub> and PM<sub>10</sub> are associated with the occurrence of multiple sclerosis relapses. Evidence from seasonal multi-pollutant analyses. Environ Res. 2018 Feb 6;163:43-52. doi: 10.1016/j.envres.2018.01.040. [Epub ahead of print] PMID: 29426027 [PubMed – as supplied by publisher]

Chronic Obstructive Pulmonary Disease (COPD) is usually thought of as a disease related to smoking.  But it is also related to air pollution exposure.

Lin H, Qian ZM, Guo Y, Zheng Y, Ai S, Hang J, Wang X, Zhang L, Liu T, Guan W, Li X, Xiao J, Zeng W, Xian H, Howard SW, Ma W, Wu F. The attributable risk of chronic obstructive pulmonary disease due to ambient fine particulate pollution among older adults. Environ Int. 2018 Feb 5;113:143-148. doi: 10.1016/j.envint.2018.01.029. [Epub ahead of print] PMID: 29425898 [PubMed – as supplied by publisher]

The American Thoracic Society has recommended lower national air quality standards than currently established by the EPA.   The ATS recommend a PM2.5 standard of 11 ug/m3 instead of 12, and an ozone standard of 60 ppm instead of 70.  This study calculates the increased mortality resulting from air pollution above the ATS suggestions.

Cromar KR, Gladson LA, Ghazipura M, Ewart G. ATS and Marron Institute Report: Estimated Excess Morbidity and Mortality Associated with Air Pollution above ATS-Recommended Standards, 2013-2015. Ann Am Thorac Soc. 2018 Feb 9. doi: 10.1513/AnnalsATS.201710-785EH. [Epub ahead of print] No abstract available.
PMID: 29425050 [PubMed – as supplied by publisher]

Air pollution increases atherosclerosis in arteries in the brain and ameliorated by consuming omega three fatty acids.

Guan L, et al. PM2.5 inhalation induces intracranial atherosclerosis which may be ameliorated by omega 3 fatty acids. Oncotarget. 2017 Dec 16;9(3):3765-3778. doi: 10.18632/oncotarget.23347. eCollection 2018 Jan 9.

 

Research Paper of the Month

Jan. 27, 2018

We highlight this paper first because one of our board members, Dr. Robert Paine, was one of the authors and the study was done here on the Wasatch Front.   Investigators from the University of Utah and Intermountain Medical Center found that the risk of pneumonia and the severity of the illness  (including ICU admission and need for critical care) was increased in response to a few days of increased PM2.5 levels.   Like with so many other studies, these effects were seen even at levels below EPA standards.

Pirozzi CS, Jones BE, VanDerslice JA, Zhang Y, Paine R, Dean N. Short-Term Air Pollution and Incident Pneumonia: A Case-Crossover Study. Ann Am Thorac Soc. 2017 Dec 28. doi: 10.1513/AnnalsATS.201706-495OC. [Epub ahead of print]

More research showing the relationship between air pollution and adverse birth outcomes.  In the case of the study below, an analysis of over 1.3 million  births in China showed not only higher rates of pre-term births with more air pollution, but the correlation was stronger the more premature the birth.

Wang YY, et al. Association of Long-term Exposure to Airborne Particulate Matter of 1 μm or Less With Preterm Birth in China. JAMA Pediatr. 2018 Jan 2:e174872. doi: 10.1001/jamapediatrics.2017.4872. [Epub ahead of print]

Air pollution exposure during the first trimester was associated with decreased weight of a pregnant mother’s placenta.

Ghasemi-Tehrani H, et al. Effect of Exposure to Air Pollution on Placental Weight in Isfahan-Iran. J Family Reprod Health. 2017 Jun;11(2):90-96.

Shutting down a coal power plant was followed by an increase in birth weight of newborns downwind from the plant.

Yang M, et al. The Impact of Environmental Regulation on Fetal Health: Evidence from the Shutdown of a Coal-Fired Power Plant Located Upwind of New Jersey. Journal of Environmental Economics and Management, 2017; DOI: 10.1016/j.jeem.2017.11.005

More evidence of air pollution contributes to metabolic disorders, i.e. type II diabetes, insulin resistance, and interferes with glucose metabolism.

Chen M, et al. Prenatal Exposure to Diesel Exhaust PM2.5 Causes Offspring β Cell Dysfunction in Adulthood.
Am J Physiol Endocrinol Metab. 2017 Dec 26. doi: 10.1152/ajpendo.00336.2017. [Epub ahead of print]

Khafaie MA, et al. Particulate matter and markers of glycemic control and insulin resistance in type 2 diabetic patients: result from Wellcome Trust Genetic study. J Expo Sci Environ Epidemiol. 2017 Dec 21. doi: 10.1038/s41370-017-0001-1. [Epub ahead of print]

Dendup T, et al. Environmental Risk Factors for Developing Type 2 Diabetes Mellitus: A Systematic Review.
Int J Environ Res Public Health. 2018 Jan 5;15(1). pii: E78. doi: 10.3390/ijerph15010078.

Bai L, et al. Exposure to Ambient Ultrafine Particles and Nitrogen Dioxide and Incident Hypertension and Diabetes.
Epidemiology. 2018 Jan 9. doi: 10.1097/EDE.0000000000000798. [Epub ahead of print]

Tan C, et al. Long-term high air pollution exposure induced metabolic adaptations in traffic policemen.
Environ Toxicol Pharmacol. 2018 Jan 5;58:156-162. doi: 10.1016/j.etap.2018.01.002. [Epub ahead of print]

More studies showing air pollution, including ozone, increases blood pressure, and the risk for hospitalization for high blood pressure

Zhang Z, et al. Long-Term Exposure to Fine Particulate Matter, Blood Pressure, and Incident Hypertension in Taiwanese Adults.  Environ Health Perspect. 2018 Jan 18;126(1):017008. doi: 10.1289/EHP2466.

Chen CC, et al. Association between gaseous air pollution and hospital admissions for hypertension in Taipei, Taiwan.
J Toxicol Environ Health A. 2017 Dec 22:1-7. doi: 10.1080/15287394.2017.1395573. [Epub ahead of print]

Two researcher papers showing that air pollution is associated with aggravation of heart failure.

Buteau S, et al. Associations between ambient air pollution and daily mortality in a cohort of congestive heart failure: Case-crossover and nested case-control analyses using a distributed lag nonlinear model. Environ Int. 2018 Jan 17. pii: S0160-4120(17)31563-5. doi: 10.1016/j.envint.2018.01.003. [Epub ahead of print]

Ji X, et al. Potential Role of Inflammation in Associations between Particulate Matter and Heart Failure. Curr Pharm Des. 2018 Jan 10. doi: 10.2174/1381612824666180110150550. [Epub ahead of print]

This study shows that air pollution is associated with increasing calcification of heart valves.

Tibuakuu M, et al. Exposure to ambient air pollution and calcification of the mitral annulus and aortic valve: the multi-ethnic study of atherosclerosis (MESA). Environ Health. 2017 Dec 21;16(1):133. doi: 10.1186/s12940-017-0346-x.

Air pollution is associated with higher risk for developing and seeking treatment for mental disorders, and a much higher mortality risk for those with mental health and behavioral disorders, including suicide.

Ho HC, et al. Spatiotemporal influence of temperature, air quality, and urban environment on cause-specific mortality during hazy days. Environment International, Volume 112, March 2018, Pages 10-22

Jia Z, et al. Exposure to Ambient Air Particles Increases the Risk of Mental Disorder: Findings from a Natural Experiment in Beijing. Int J Environ Res Public Health. 2018 Jan 19;15(1). pii: E160. doi: 10.3390/ijerph15010160.

Oudin A, et al. The association between daily concentrations of air pollution and visits to a psychiatric emergency unit: a case-crossover study.Environ Health. 2018 Jan 10;17(1):4. doi: 10.1186/s12940-017-0348-8.

Casas L, et al. Does air pollution trigger suicide? A case-crossover analysis of suicide deaths over the life span
European Journal of Epidemiology. November 2017, Volume 32, Issue 11, pp 973–981  

A good review article on how environmental contaminates like air pollution affect the brain in males much more than females

Kern JK, et al. Developmental neurotoxicants and the vulnerable male brain: a systematic review of suspected neurotoxicants that disproportionally affect males. Acta Neurobiol Exp (Wars). 2017;77(4):269-296.

More evidence of air pollution increasing a person’s risk for stroke.

Guan T, et al. Differential Susceptibility in Ambient Particle-Related First-Ever Stroke Onset Risk: Findings From a National Case-Crossover Study. Am J Epidemiol. 2018 Jan 17. doi: 10.1093/aje/kwy007. [Epub ahead of print]

This study showed that a biological pathway for air pollution’s involvement in strokes and heart attacks is the release of inflammatory chemicals that alter the functioning of genes involved in the regulation of blood vessels.

Chen R, et al. Fine Particulate Air Pollution and the Expression of microRNAs and Circulating Cytokines Relevant to Inflammation, Coagulation, and Vasoconstriction. Environ Health Perspect. 2018 Jan 17;126(1):017007. doi: 10.1289/EHP1447.

This study in mice shows that an anti-oxidant in grapefruit, reduces the DNA damage and oxidative stress in heart cells, and the tendency for blood clot formation caused by diesel exhaust.  This is just one study, but there’s no down side to eating more grapefruit.

Nemmar A, et al. Thrombosis, systemic and cardiac oxidative stress and DNA damage induced by pulmonary exposure to diesel exhaust particles, and the effect of nootkatone thereon. Am J Physiol Heart Circ Physiol. 2018 Jan 5. doi: 10.1152/ajpheart.00313.2017. [Epub ahead of print]

Multiple studies have shown air pollution affects male sperm.  The studies below add to that data base, including one that shows it reduces the y/x chromosome ratio in sperm which would result in a decrease in percentage of male newborns compared to females.

Radwan M, et al. Air Pollution and Human Sperm Sex Ratio. Am J Mens Health. 2018 Jan 1:1557988317752608. doi: 10.1177/1557988317752608. [Epub ahead of print]

Zhou N, et al. Exposures to Atmospheric PM10 and PM10-2.5 Affect Male Semen Quality: Results of MARHCS Study.
Environ Sci Technol. 2018 Jan 11. doi: 10.1021/acs.est.7b05206. [Epub ahead of print]

This is the first study we know of to show that air pollution affects menstruation, delaying the onset of menstrual regularity in exposed teenage girls.

Mahalingaiah S, et al. Perimenarchal air pollution exposure and menstrual disorders. Human Reproduction, 2018; DOI: 10.1093/humrep/dey005

Air pollution even of only a few days duration, increases the risk of bronchiolitis and otitis media in infants, especially those born prematurely

Girguis MS, et al. Exposure to acute air pollution and risk of bronchiolitis and otitis media for preterm and term infants.
J Expo Sci Environ Epidemiol. 2017 Dec 21. doi: 10.1038/s41370-017-0006-9. [Epub ahead of print]

Dec. 19, 2017

Research Paper of the Month

Hundreds of studies have shown increased overall mortality from air pollution, most of that is assumed to occur in the vulnerable subsets of the adult population, especially the elderly.  Far fewer studies have been done exploring possible increased rates of infant mortality.  The study below adds significantly to the evidence that air pollution also contributes to infant mortality.  Almost 500,000 infants were tracked for over 6 years.  Researchers found a very strong association between small increases in PM2.5  and total infant deaths, respiratory deaths, and SIDS.  Specifically 1.3 ug/m3 increases in PM2.5 increased the rate of these outcomes between 200% and 300%.

Son JY, et al. Pregnancy and Lifetime Exposure to Fine Particulate Matter and Infant Mortality in Massachusetts, 2001-2007.  Am J Epidemiol. 2017 Nov 7:1-9. doi: 10.1093/aje/kwx015. [Epub ahead of print]

Acceleration of the aging process is part of the clinical consequence of air pollution exposure.  Telomere length is a marker of biological aging.    This study showed that prenatal air pollution provokes shorter telomere length in the newborns, measured in the umbilical cord and placenta.

Martens DS, et al. Prenatal Air Pollution and Newborns’ Predisposition to Accelerated Biological Aging.
JAMA Pediatr. 2017 Oct 16. doi: 10.1001/jamapediatrics.2017.3024. [Epub ahead of print]

More evidence that air pollution triggers lung cancer.

Lamichhane DK, et al. Lung Cancer Risk and Residential Exposure to Air Pollution: A Korean Population-Based Case-Control Study.  Yonsei Med J. 2017 Nov;58(6):1111-1118. doi: 10.3349/ymj.2017.58.6.1111.

Air pollution and a more deprived social environment both contribute to lower intellectual scores in children.

Lett LA, et al. The Combined Influence of Air Pollution and Home Learning Environment on Early Cognitive Skills in Children.  Int J Environ Res Public Health. 2017 Oct 26;14(11). pii: E1295. doi: 10.3390/ijerph14111295.

Given that inflammation is the biological pathway through which air pollution causes many diseases, for this study to find an exacerbation of lupus with air pollution is not at all surprising.

Alves AGF, et al. Influence of air pollution on airway inflammation and disease activity in childhood-systemic lupus erythematosus. Clin Rheumatol. 2017 Nov 2. doi: 10.1007/s10067-017-3893-1. [Epub ahead of print] 

Numerous new studies showing air pollution’s association with adverse pregnancy outcomes, especially low birth weight syndrome.

Wu H, et al. Exposure to fine particulate matter during pregnancy and risk of term low birth weight in Jinan, China, 2014-2016.
Int J Hyg Environ Health. 2017 Oct 28. pii: S1438-4639(17)30399-1. doi: 10.1016/j.ijheh.2017.10.013. [Epub ahead of print]

Ji Y, et al. Association between exposure to particulate matter during pregnancy and birthweight: a systematic review and a meta-analysis of birth cohort studies. J Biomed Res. 2017 Nov 1. doi: 10.7555/JBR.31.20170038. [Epub ahead of print]

Dutta A, et al. Household air pollution and chronic hypoxia in the placenta of pregnant Nigerian women: A randomized controlled ethanol Cookstove intervention. Sci Total Environ. 2017 Nov 14;619-620:212-220. doi: 10.1016/j.scitotenv.2017.11.091. [Epub ahead of print]

Smith R, et al. Impact of London’s road traffic air and noise pollution on birth weight: retrospective population based cohort study. BMJ, 2017; j5299 DOI: 10.1136/bmj.j5299

Air pollution exposure of a mother, measured one month prior to conception and one month after shows higher rates of congenital malformations, especially of the heart.

Ren S, et al. Periconception Exposure to Air Pollution and Risk of Congenital Malformations. The Journal of Pediatrics, 2017; DOI: 10.1016/j.jpeds.2017.09.076

Air pollution affects the brain in multiple ways.  This shows that it increases the delinquent behavior of adolescents, much like lead does.

Younan D, et al. Longitudinal Analysis of Particulate Air Pollutants and Adolescent Delinquent Behavior in Southern California. Journal of Abnormal Child Psychology, 2017; DOI: 10.1007/s10802-017-0367-5

This study shows that attention span in school children is impaired by the air pollution they breathed on the way to school.

Sunyer J, et al. Traffic-related Air Pollution and Attention in Primary School Children: Short-term Association.  Epidemiology: March 2017 – Volume 28 – Issue 2 – p 181–189. doi: 10.1097/EDE.0000000000000603

Two more studies that show a connection between air pollution and autism.   The first study showed that the affect could be mitigated by maternal extra consumption of folic acid.

Goodrich AJ, et al. Joint effects of prenatal air pollutant exposure and maternal folic acid supplementation on risk of autism spectrum disorder. Autism Res. 2017 Nov 9. doi: 10.1002/aur.1885. [Epub ahead of print]

Li K, et al. Early postnatal exposure to airborne fine particulate matter induces autism-like phenotypes in male rats.  Toxicol Sci. 2017 Nov 7. doi: 10.1093/toxsci/kfx240. [Epub ahead of print]

Evidence for a mechanism of how prenatal air pollution exposure may be associated with increased risk of childhood obesity.

Alderete TL, et al. Prenatal traffic-related air pollution exposures, cord blood adipokines and infant weight. Pediatr Obes. 2017 Nov 3. doi: 10.1111/ijpo.12248. [Epub ahead of print]

This is first study we know of to show that osteoporosis is associated with air pollution exposure.

Prada, D, Zhong, J, Colicino, E et al. Association of air particulate pollution with bone loss over time and bone fracture risk: analysis of data from two independent studies. Lancet Planet Health. 2017; 1: e337–e347

Air pollution degrades the inside lining of the nose.

Zhao R, et al. Nasal epithelial barrier disruption by particulate matter ≤2.5 μm via tight junction protein degradation.
J Appl Toxicol. 2017 Dec 13. doi: 10.1002/jat.3573. [Epub ahead of print]

Biomass smoke (like wood) causes DNA damage in cell death in the lung.

de Oliveira Alves N, et al. Biomass burning in the Amazon region causes DNA damage and cell death in human lung cells. Scientific Reports, 2017; 7 (1) DOI: 10.1038/s41598-017-11024-3

Numerous new studies on the association between air pollution and premature death.

Kim SE, et al. Associations between mortality and prolonged exposure to elevated particulate matter concentrations in East Asia.  Environ Int. 2017 Oct 30. pii: S0160-4120(17)30909-1. doi: 10.1016/j.envint.2017.10.010. [Epub ahead of print]

Fang X, et al. Relationship between fine particulate matter, weather condition and daily non-accidental mortality in Shanghai, China: A Bayesian approach. PLoS One. 2017 Nov 9;12(11):e0187933. doi: 10.1371/journal.pone.0187933. eCollection 2017.

Holnicki P, et al. Burden of Mortality and Disease Attributable to Multiple Air Pollutants in Warsaw, Poland.  Int J Environ Res Public Health. 2017 Nov 8;14(11). pii: E1359. doi: 10.3390/ijerph14111359.

Cappellari M, et al. Association between short- and medium-term air pollution exposure and risk of mortality after intravenous thrombolysis for stroke. J Thromb Thrombolysis. 2017 Nov 28. doi: 10.1007/s11239-017-1589-7. [Epub ahead of print]

Corrigan AE, et al. Fine particulate matters: The impact of air quality standards on cardiovascular mortality.  Environ Res. 2017 Nov 28;161:364-369. doi: 10.1016/j.envres.2017.11.025. [Epub ahead of print]

Parker JD, et al. Particulate Matter Air Pollution Exposure and Heart Disease Mortality Risks by Race and Ethnicity in the United States: 1997-2009 NHIS with Mortality Followup Through 2011. Circulation. 2017 Dec 13. pii: CIRCULATIONAHA.117.029376. doi: 10.1161/CIRCULATIONAHA.117.029376. [Epub ahead of print]

In this rather elaborate study, the heart and lung benefits of exercise walking were offset by air pollution inhaled along a busy road.

Sinharay R, et al. Respiratory and cardiovascular responses to walking down a traffic-polluted road compared with walking in a traffic-free area in participants aged 60 years and older with chronic lung or heart disease and age-matched healthy controls: a randomised, crosso. The Lancet, 2017; DOI:

More evidence that air pollution increases blood pressure

Magalhaes S, et al. Impacts of exposure to black carbon, elemental carbon, and ultrafine particles from indoor and outdoor sources on blood pressure in adults: A review of epidemiological evidence. Environ Res. 2017 Nov 28;161:345-353. doi: 10.1016/j.envres.2017.11.030. [Epub ahead of print]

This study in animals shows impaired sperm production with air pollution  exposure

Qiu L, et al. Exposure to Concentrated Ambient PM2.5 Compromises Spermatogenesis in a Mouse Model: Role of Suppression of Hypothalamus-Pituitary-Gonads Axis. Toxicol Sci. 2017 Nov 20. doi: 10.1093/toxsci/kfx261. [Epub ahead of print]

 

Oct. 16, 2017

Research Paper of the Month

We have stated previously that air pollution harms all major organ systems.  The evidence for an affect on kidneys has been sparse however.  This new study shows evidence that air pollution has a significant association with impaired kidney function.

Bowe B, et al. Particulate Matter Air Pollution and the Risk of Incident CKD and Progression to ESRD.  J Am Soc Nephrol. 2017 Sep 21. pii: ASN.2017030253. doi: 10.1681/ASN.2017030253. [Epub ahead of print]

Another study showing air pollution’s connection to rates of strokes.

Guo P, et al. Ambient Air Pollution and Risk for Ischemic Stroke: A Short-Term Exposure Assessment in South China.  Int J Environ Res Public Health. 2017 Sep 20;14(9). pii: E1091. doi: 10.3390/ijerph14091091.

More evidence of the harm that air pollution provokes on fetal development, placental growth and pregnancy outcomes.

Blum J, et al. Exposure to Ambient Particulate Matter during Specific Gestational Periods Produces Adverse Obstetric Consequences in Mice. Environmental Health Perspectives, July 2017 DOI: 10.1289/EHP1029

Soto SF, et al. Exposure to fine particulate matter in the air alters placental structure and the renin-angiotensin system. PLoS One. 2017 Aug 18;12(8):e0183314. doi: 10.1371/journal.pone.0183314. eCollection 2017.

Reis MMD, et al. Air pollution and low birth weight in an industrialized city in Southeastern Brazil, 2003-2006. Rev Bras Epidemiol. 2017 Apr-Jun;20(2):189-199. doi: 10.1590/1980-5497201700020001.

Clemens T, et al. Maternal exposure to ambient air pollution and fetal growth in North-East Scotland: A population-based study using routine ultrasound scans. Environ Int. 2017 Oct;107:216-226. doi: 10.1016/j.envint.2017.07.018. Epub 2017 Jul 25.

Kingsley SL, et al. Maternal residential air pollution and placental imprinted gene expression.  Environ Int. 2017 Sep 5;108:204-211. doi: 10.1016/j.envint.2017.08.022. [Epub ahead of print]

Wang L, et al. The association between cooking oil fume exposure during pregnancy and birth weight: A prospective mother-child cohort study. Sci Total Environ. 2017 Sep 4;612:822-830. doi: 10.1016/j.scitotenv.2017.08.031. [Epub ahead of print]

Air pollution is associated with brain diseases and dysfunction.  This study adds to the evidence that air pollution contributes to depression.

Lin H, et al. Exposure to air pollution and tobacco smoking and their combined effects on depression in six low- and middle-income countries. Br J Psychiatry. 2017 Aug 10. pii: bjp.bp.117.202325. doi: 10.1192/bjp.bp.117.202325. [Epub ahead of print]

Another study showing that air pollution impairs cognitive abilities of children.  In particular these studies measured the amount of air pollution that children breathed on the way to school, which correlated with decreased memory.

Forns J, et al. Longitudinal association between air pollution exposure at school and cognitive development in school children over a period of 3.5 years. Environ Res. 2017 Aug 28;159:416-421. doi: 10.1016/j.envres.2017.08.031. [Epub ahead of print]

Alvarez-Pedrerol M, et al. Impact of commuting exposure to traffic-related air pollution on cognitive development in children walking to school. Environmental Pollution, 2017; 231: 837 DOI: 10.1016/j.envpol.2017.08.075

More studies showing air pollution’s strong association with Alzheimer’s, dementia, and the anatomic changes in the brain associated with these disorders

Hullmann M, et al. Diesel engine exhaust accelerates plaque formation in a mouse model of Alzheimer’s disease. Part Fibre Toxicol. 2017 Aug 30;14(1):35. doi: 10.1186/s12989-017-0213-5.

Chen H, et al. Exposure to ambient air pollution and the incidence of dementia: A population-based cohort study. Environment International. Volume 108, November 2017, Pages 271-277

Another study showing air pollution’s connection to premature death, in this case due to cardiovascular disease, and more pronounced in women.

Zhang C, et al. Association between air pollution and cardiovascular mortality in Hefei, China: A time-series analysis. Environ Pollut. 2017 Aug 7. pii: S0269-7491(16)32799-3. doi: 10.1016/j.envpol.2017.06.022. [Epub ahead of print]

Benzene, SO2, and NOx were associated with increased rates of lung and bladder cancer, primarily in women over the age of 75.

Collarile P, et al. Residence in Proximity of a Coal-Oil-Fired Thermal Power Plant and Risk of Lung and Bladder Cancer in North-Eastern Italy. A Population-Based Study: 1995-2009.

In utero exposure to air pollution, specifically diesel exhaust, has been shown in animals to lead to heart failure in adulthood.  This study showed that a likely mechanism is the alteration of genes that play a role in the the functioning of heart cells.

Goodson J, et al. In utero exposure to diesel exhaust particulates is associated with an altered cardiac transcriptional response to transverse aortic constriction and altered DNA methylation. The FASEB Journal, 2017; fj.201700032R DOI: 10.1096/fj.201700032R

This study shows that in healthy college age students, higher air pollution led to significant increases in stress hormones–cortisol, cortisone, epinephrine, and norepinephrine, higher blood pressure, insulin resistance, and biomarkers of oxidative stress and inflammation

Li H, et al. Particulate Matter Exposure and Stress Hormone Levels: A Randomized, Double-Blind, Crossover Trial of Air Purification. https://doi.org/10.1161/CIRCULATIONAHA.116.026796 Circulation. 2017;136:618-627

More studies that strengthen the connection between air pollution and type II diabetes.

Mazidi M, et al. Ambient particulate air pollution (PM2.5) is associated with the ratio of type 2 diabetes to obesity. Sci Rep. 2017 Aug 22;7(1):9144. doi: 10.1038/s41598-017-08287-1.

Strak M, et al. Long-term exposure to particulate matter, NO2 and the oxidative potential of particulates and diabetes prevalence in a large national health survey. Environ Int. 2017 Sep 5;108:228-236. doi: 10.1016/j.envint.2017.08.017. [Epub ahead of print]

More studies showing particulate pollution’s alteration of the functioning of genes.

Huang Q, et al. Fine particulate matter 2.5 exerted its toxicological effect by regulating a new layer, long non-coding RNA. Sci Rep. 2017 Aug 24;7(1):9392. doi: 10.1038/s41598-017-09818-6.

de Oliveira A, et al. Biomass burning in the Amazon region causes DNA damage and cell death in human lung cells. Sci Rep. 2017 Sep 7;7(1):10937. doi: 10.1038/s41598-017-11024-3.

More evidence that air pollution shortens life expectancy and causes premature death.

Ebenstein A, et al. New evidence on the impact of sustained exposure to air pollution on life expectancy from China’s Huai River Policy. Proceedings of the National Academy of Sciences, 2017; 201616784 DOI: 10.1073/pnas.1616784114

Huang C, et al. Potential Cardiovascular and Total Mortality Benefits of Air Pollution Control in Urban China.  Circulation. 2017 Sep 7. pii: CIRCULATIONAHA.116.026487. doi: 10.1161/CIRCULATIONAHA.116.026487. [Epub ahead of print.

Malley C, et al. Updated Global Estimates of Respiratory Mortality in Adults ≥30 Years of Age Attributable to Long-Term Ozone Exposure. Environ Health Perspect; DOI:10.1289/EHP1390

Blount, R, et al. Traffic-Related Air Pollution and All-Cause Mortality during Tuberculosis Treatment in California.  Environ Health Perspect; DOI:10.1289/EHP1699

Inhalation of particles is different depending on the age of the person.  Particle deposition  highest in an infant, less in an older child, and lowest in an adult.

Deng Q, et al. Particle deposition in tracheobronchial airways of an infant, child and adult. Sci Total Environ. 2017 Aug 27;612:339-346. doi: 10.1016/j.scitotenv.2017.08.240. [Epub ahead of print]

Another study that shows a connection between air pollution and malignant brain tumors

Andersen Z, et al. Long-term Exposure to Ambient Air Pollution and Incidence of Brain Tumor: the European Study of Cohorts for Air Pollution Effects (ESCAPE). Neuro Oncol. 2017 Aug 31. doi: 10.1093/neuonc/nox163. [Epub ahead of print]

More evidence that air pollution is associated with increased susceptibility to heart failure

Sørensen M, et al. Long-Term Exposure to Road Traffic Noise and Nitrogen Dioxide and Risk of Heart Failure: A Cohort Study. Environ Health Perspect. 2017 Sep 26;125(9):097021. doi: 10.1289/EHP1272.

Epigenetic changes has been found to play a role in the inflammation cascade triggered by air pollution.

Wang C, et al. Acute Inflammation Following Personal Exposure to Fine-particulate Air Pollution.  Am J Epidemiol. 2017 Aug 17. doi: 10.1093/aje/kwx277. [Epub ahead of print]

 

Aug. 5, 2017

Research Paper of the Month

Both chronic and acute ozone exposure during pregnancy increase the risk of still birth, as much as 39% even at levels below the EPA’s standards.  Even the ozone levels in the week prior to delivery increase the risk.  About 8,000 still births a year occur nationally due to ozone.  Extrapolating from that research to Utah indicates about 100 still births a year occur in Utah due to our ozone, and that doesn’t count the risk of PM2.5.

Mendola P, Ha S, Pollack AZ, Zhu Y, Seeni I, Kim SS, Sherman S, Liu D. Chronic and Acute Ozone Exposure in the Week Prior to Delivery Is Associated with the Risk of Stillbirth.Int J Environ Res Public Health. 2017 Jul 6;14(7). pii: E731. doi: 10.3390/ijerph14070731.

Even air pollution levels slightly above background levels are associated withe increased rates of hospitalization for all causes, and for respiratory and heart problems in particular. Like other studies on mortality, the rate of increase per unit of exposure, was even greater at PM 2.5 levels below 8 ug/m3. The current annual EPA standard is 12. Background levels of PM2.5 are about 5 ug/m3.

Makar M, Antonelli J, Di Q, Cutler D, Schwartz J, Dominici F. Estimating the Causal Effect of Low Levels of Fine Particulate Matter on Hospitalization. Epidemiology. 2017 Sep;28(5):627-634. doi: 10.1097/EDE.0000000000000690.

Ozone is associated with increased rates of hospitalizations for heart attacks.

Chiu HF, Weng YH, Chiu YW, Yang CY. Short-Term Effects of Ozone Air Pollution on Hospital Admissions for Myocardial Infarction: A Time-Stratified Case-Crossover Study in Taipei. J Toxicol Environ Health A. 2017 Jun 9:1-7. doi: 10.1080/15287394.2017.1321092. [Epub ahead of print]

Air pollution exposure of a pregnant mother increases the likelihood of obesity later on in childhood.

Mao G, et al. Individual and Joint Effects of Early-Life Ambient PM2.5 Exposure and Maternal Prepregnancy Obesity on Childhood Overweight or Obesity. Environ Health Perspect; DOI:10.1289/EHP261

More evidence that air pollution increases the risk of intrauterine growth retardation, small for gestational weight babies, and premature births.

Basu R, et al. Association between PM2.5 and PM2.5 Constituents and Preterm Delivery in California, 2000-2006.
Paediatr Perinat Epidemiol. 2017 Jul 21. doi: 10.1111/ppe.12380. [Epub ahead of print]

Clemens T, Turner S, Dibben C. Maternal exposure to ambient air pollution and fetal growth in North-East Scotland: A population-based study using routine ultrasound scans. Environ Int. 2017 Jul 25;107:216-226. doi: 10.1016/j.envint.2017.07.018. [Epub ahead of print]

Liu C, et al. Different exposure levels of fine particulate matter and preterm birth: a meta-analysis based on cohort studies. Environ Sci Pollut Res Int. 2017 Jun 15. doi: 10.1007/s11356-017-9363-0. [Epub ahead of print]

Several recent studies strengthening the connection between air pollution and cancer, especially breast cancer.

Sifaki-Pistolla D, Lionis C, Koinis F, Georgoulias V, Tzanakis N; On behalf of the Cancer Registry of Crete (CRC). Lung cancer and annual mean exposure to outdoor air pollution in Crete, Greece. Eur J Cancer Prev. 2017 Jul 25. doi: 10.1097/CEJ.0000000000000407. [Epub ahead of print]

White AJ, et al. Indoor Wood-Burning Stove and Fireplace Use and Breast Cancer in a Prospective Cohort Study. Environ Health Perspect. 2017 Jul 18;125(7):077011. doi: 10.1289/EHP827.

Large C, Wei Y. Geographic variations in female breast cancer incidence in relation to ambient air emissions of polycyclic aromatic hydrocarbons. Environ Sci Pollut Res Int. 2017 Jun 14. doi: 10.1007/s11356-017-9395-5. [Epub ahead of print]

Goldberg MS, et al. The association between the incidence of postmenopausal breast cancer and concentrations at street-level of nitrogen dioxide and ultrafine particles. Environ Res. 2017 Jun 5;158:7-15. doi: 10.1016/j.envres.2017.05.038. [Epub ahead of print]

Air pollution reduces survival after the diagnosis of liver cancer

Deng H, et al. Particulate matter air pollution and liver cancer survival. Int J Cancer. 2017 Jun 7. doi: 10.1002/ijc.30779. [Epub ahead of print]

More evidence that air pollution is a risk factor for inflammatory bowel disease.

van der Sloot KWJ, Amini M, Peters V, Dijkstra G, Alizadeh BZ. Inflammatory Bowel Diseases: Review of Known Environmental Protective and Risk Factors Involved. Inflamm Bowel Dis. 2017 Aug 2. doi: 10.1097/MIB.0000000000001217. [Epub ahead of print]

More evidence that even short term air pollution decreases lung function in otherwise healthy adults

Panis L, Provost EB, Cox B, Louwies T, Laeremans M, Standaert A, Dons E, Holmstock L, Nawrot T, De Boever P.  Short-term air pollution exposure decreases lung function: a repeated measures study in healthy adults. Environ Health. 2017 Jun 14;16(1):60. doi: 10.1186/s12940-017-0271-z.  PMID: 28615020 [PubMed – in process]

New-England-Journal-of-Medicine

July 10, 2017

Research Paper of the Month

This is a landmark study on air pollution and mortality, involving 61 million people from throughout the country.  It is published in the most prestigious journal in the world, the New England Journal of Medicine.  It significantly strengthens the association between premature death and PM2.5 and ozone.  The key findings were that levels of both pollutants, well below the EPA’s standards are still strongly associated with mortality.  Specifically, for every 10 ug/m3 of chronic PM2.5 exposure mortality in 7.3%, or .73% for every 1 ug/m3.  For ozone, for every 10 ppb, the mortality increased 1.1%.  However, at lower concentrations, that association was even stronger.  For those people exposed to levels of PM2.5 below 12 ug/m3 (the current EPA annual standard), and below 50 ppb ozone (the current EPA standard is 70 ppb), the risk of death increased to 1.36% for every 1 ug/m3 for PM2.5, and continued at the same rate for ozone, i.e. 1% for every 10 ppb.

This is the strongest research statement yet to establish that:  1.  There is no safe level of air pollution.  2.  Current EPA standards are inadequate and out of step with the science.  3.  The health hazard per unit off exposure is actually greater at the lowest doses.  That means public policy needs to address the problem even for those cities that have relatively clean air.  4.  The current administration’s attempt to delay or role back standards will do even more harm than what has been previously calculated.

Di Q, et al. Air Pollution and Mortality in the Medicare Population. New England Journal of Medicine, 2017; 376 (26): 2513 DOI: 10.1056/NEJMoa1702747

 

_90981685_amyloidplaque_spl

The subjects in this study below were children, teenagers, and young adults in Mexico City where the particulate pollution is still quite high, despite many public policy changes to address it.   This is the second study to show that these tiny pollution nanoparticles from fossil fuel combustion end up inside our brains.  Once there they can cause brain damage, disrupting cellular and intracellular architecture.  This undoubtedly contributes to the many clinical studies that show impaired brain function, loss of memory, loss of intellectual abilities, behavior problems, and more degenerative brain diseases in people exposed to more air pollution.

We should be just as concerned about the air our children breathe as we are about lead in the water they drink.

González-Maciel A, Reynoso-Robles R, Torres-Jardón R, Mukherjee PS, Calderón-Garcidueñas L. Combustion-Derived Nanoparticles in Key Brain Target Cells and Organelles in Young Urbanites: Culprit Hidden in Plain Sight in Alzheimer’s Disease Development. J Alzheimers Dis. 2017 Jun 3. doi: 10.3233/JAD-170012. [Epub ahead of print]

This study shows that heart function is impaired with air pollution.

Yang WY, et al. Left ventricular function in relation to chronic residential air pollution in a general population.  Eur J Prev Cardiol. 2017 Jan 1:2047487317715109. doi: 10.1177/2047487317715109. [Epub ahead of print]

Good review on the broad based health consequences of ozone.   Think of it as slightly less toxic than particulate pollution.

Nuvolone D, Petri D, Voller F. The effects of ozone on human health. Environ Sci Pollut Res Int. 2017 May 25. doi: 10.1007/s11356-017-9239-3. [Epub ahead of print]

Numerous studies are showing a strong connection between pollution and type II diabetes.  This study of newborns showed an increase in insulin levels, measured from cord blood, with more particulate pollution exposure.  Specifically, for every 2.4 ug/m3 increase in PM2.5, insulin levels increased 13%.  This suggests that pollution in utero can set the stage for type II diabetes later in life.

Madhloum N, et al. Cord plasma insulin and in utero exposure to ambient air pollution. Environ Int. 2017 May 22. pii: S0160-4120(16)30886-8. doi: 10.1016/j.envint.2017.05.012. [Epub ahead of print]

Air pollution can adversely affect heart rhythm.

Carll AP, et al. Inhaled ambient-level traffic-derived particulates decrease cardiac vagal influence and baroreflexes and increase arrhythmia in a rat model of metabolic syndrome. Part Fibre Toxicol. 2017 May 25;14(1):16. doi: 10.1186/s12989-017-0196-2.

Air pollution found to reduce survival after diagnosis of liver cancer

Deng H, et al. Particulate matter air pollution and liver cancer survival. Int J Cancer. 2017 Jun 7. doi: 10.1002/ijc.30779. [Epub ahead of print]

Two more studies showing a relationship between air pollution and breast cancer.

Goldberg MS, et al. The association between the incidence of postmenopausal breast cancer and concentrations at street-level of nitrogen dioxide and ultrafine particles. Environ Res. 2017 Jun 5;158:7-15. doi: 10.1016/j.envres.2017.05.038. [Epub ahead of print]

Large C, Wei Y.  Geographic variations in female breast cancer incidence in relation to ambient air emissions of polycyclic aromatic hydrocarbons.  Environ Sci Pollut Res Int. 2017 Jun 14. doi: 10.1007/s11356-017-9395-5. [Epub ahead of print]  

Ozone is associated with increased rates of hospitalizations for heart attacks.

Chiu HF, Weng YH, Chiu YW, Yang CY. Short-Term Effects of Ozone Air Pollution on Hospital Admissions for Myocardial Infarction: A Time-Stratified Case-Crossover Study in Taipei. J Toxicol Environ Health A. 2017 Jun 9:1-7. doi: 10.1080/15287394.2017.1321092. [Epub ahead of print]

Yet another study showing increased incidence of premature birth with air pollution.  The evidence is now overwhelming.

Liu C, et al. Different exposure levels of fine particulate matter and preterm birth: a meta-analysis based on cohort studies. Environ Sci Pollut Res Int. 2017 Jun 15. doi: 10.1007/s11356-017-9363-0. [Epub ahead of print]

Short term air pollution decreases lung function in healthy adults.

Panis L, Provost EB, Cox B, Louwies T, Laeremans M, Standaert A, Dons E, Holmstock L, Nawrot T, De Boever P.  Short-term air pollution exposure decreases lung function: a repeated measures study in healthy adults. Environ Health. 2017 Jun 14;16(1):60. doi: 10.1186/s12940-017-0271-z.

May 27, 2017

Research Paper of the Month

This paper gives us new insight into how particulate pollution causes vascular dysfunction, leading to such things heart attacks and strokes.  Inhaled nanoparticles were found to accumulate in the lining of blood vessels at sites of existing  inflammation and atherosclerosis, aggravating that disease process.  The particles appeared in the blood and urine of human subjects within as little as 15 minutes, and were still present three months later.

Miller MR, et al. Inhaled Nanoparticles Accumulate at Sites of Vascular Disease. ACS Nano. 2017 Apr 26. doi: 10.1021/acsnano.6b08551. [Epub ahead of print]

Telomeres are repeating sequences of DNA at the ends of chromosomes that keep the chromosomes from unraveling.  Every time the cell divides it loses some telomere length.  Telomere length is closely associated with longevity.  Previous studies have shown air pollution is associated with shorter placental and fetal telomere length.  This study shows that in children and adolescents, air pollution exposure is associated with reduced telomere length, and that means reduced life expectancy.

Lee E, et al.  Traffic-Related Air Pollution and Telomere Length in Children and Adolescents Living in Fresno, CA. Journal of Occupational and Environmental Medicine, 2017; 59 (5): 446 DOI: 10.1097/JOM.0000000000000996  

As the connection between air pollution and neurodegenerative diseases steadily grows, this is one we didn’t anticipate–air pollution aggravating symptoms of Parkinson’s disease.

Lee H, Myung W, Kim DK, Kim SE, Kim CT, Kim H. Short-term air pollution exposure aggravates Parkinson’s disease in a population-based cohort. Sci Rep. 2017 Mar 16;7:44741. doi: 10.1038/srep44741.

Another study showing that air pollution impairs the vascular architecture of the placenta.

Hettfleisch, K, et al. Short-Term Exposure to Urban Air Pollution and Influences on Placental Vascularization Indexes. Environ Health Perspect; DOI:10.1289/EHP300

Evidence of air pollution’s adverse effect on pregnancy is now overwhelming.  In this study particulate pollution was associated with a decrease in fetal thyroid hormone (TSH) and decreased.

Janssen BG, et al. Fetal Thyroid Function, Birth Weight, and in Utero Exposure to Fine Particle Air Pollution: A Birth Cohort Study. Environ Health Perspect; DOI:10.1289/EHP508

Another study showing the connection between air pollution and another pregnancy complication–gestational hypertension.

Zhu Y, et al. Ambient air pollution and risk of gestational hypertension. Am J Epidemiol. 2017 May 4. doi: 10.1093/aje/kwx097. [Epub ahead of print]

Two more studies showing air pollution damages DNA by altering “epigenetics,” the chemical bath that chromosomes sit in.

Lai CH, et al. Exposure to fine particulate matter causes oxidative and methylated DNA damage in young adults: A longitudinal study. Sci Total Environ. 2017 Apr 23;598:289-296. doi: 10.1016/j.scitotenv.2017.04.079. [Epub ahead of print]

Ding R, et al. Dose- and time- effect responses of DNA methylation and histone H3K9 acetylation changes induced by traffic-related air pollution. Sci Rep. 2017 Mar 3;7:43737. doi: 10.1038/srep43737.

Another study showing air pollution impairs our mental health, i.e.  is associated with higher rates of anxiety and depression.

Pun VC, et al. Association of Ambient Air Pollution with Depressive and Anxiety Symptoms in Older Adults: Results from the NSHAP Study. Environ Health Perspect; DOI:10.1289/EHP494

March 7, 2017

Air pollution accelerates brain aging, increases the deposition of amyloid beta particles in the brain, and can almost double the risk of Alzheimer’s in elderly women.  Put another way, air pollution appears to be responsible for 20% of Alzheimer’s.  A critical Alzheimer risk gene, magnifies the risk further, especially in women, and interacts with air pollution to accelerate brain aging.

Cacciottolo M, et al. Particulate air pollutants, APOE alleles and their contributions to cognitive impairment in older women and to amyloidogenesis in experimental models. Translational Psychiatry (2017) 7, e1022; doi:10.1038/tp.2016.280 Published online 31 January 2017

Feb. 27, 2017

Research paper of the month

pahshort

This study suggests that the real culprit in particulate air pollution’s adverse effect on pregnancy outcomes is PAHs which are often attached to air pollution particles, rather than the particles themselves.  More evidence that not all air pollution is created equal, and we should be paying much more attention to those sources that create high levels of PAH pollution–wood smoke, and industrial pollution.

Jedrychowski WA, Majewska R, Spengler JD, Camann D, Roen EL, Perera FP. Prenatal exposure to fine particles and polycyclic aromatic hydrocarbons and birth outcomes: a two-pollutant approach. Int Arch Occup Environ Health. 2017 Feb 7. doi: 10.1007/s00420-016-1192-9. [Epub ahead of print]

The most toxic type of particulate pollution is the ultrafine category, i.e. less than 0.1 micron is size. Ultrafine pollution exposure is associated with accelerated atherosclerosis and increased rates of inflammatory bowel disease. This study reveals a likely mechanism. Ultrafines can be inhaled or ingested. This study shows that ingested ultrafine pollution altered the microbial make up of the bowel, and increased atherogenic lipid metabolites.

Li R, et al. Ambient Ultrafine Particle Ingestion Alters Gut Microbiota in Association with Increased Atherogenic Lipid Metabolites. Sci Rep. 2017 Feb 17;7:42906. doi: 10.1038/srep42906.

Outdoor air pollution has been linked to 2.7 million preterm births per year, 18% of all pre-term births.

Christopher S. Malley, Johan C.I. Kuylenstierna, Harry W. Vallack, Daven K. Henze, Hannah Blencowe, Mike R. Ashmore. Preterm birth associated with maternal fine particulate matter exposure: A global, regional and national assessment. Environment International, 2017; DOI: 10.1016/j.envint.2017.01.023

The closer you live to a major traffic corridor, the greater your chance of developing dementia.  More evidence of the neurotoxicity of air pollution.

Chen H, et al. Living near major roads and the incidence of dementia, Parkinson’s disease, and multiple sclerosis: a population-based cohort study. Published: 04 January 2017 DOI: http://dx.doi.org/10.1016/S0140-6736(16)32399-6

Another cancer associated with air pollution—liver cancer.

Pedersen M, et al. Ambient air pollution and primary liver cancer incidence in four European cohorts within the ESCAPE project. Environ Res. 2017 Jan 17;154:226-233. doi: 10.1016/j.envres.2017.01.006. [Epub ahead of print]

 

Dec. 30, 2016

Research paper of the month

TT collapse

The 9/11 dust cloud from the collapse of the Twin Towers in 2001, was shown to be associated with significantly higher rates of premature birth and low birth wt in the babies of pregnant women in Manhattan, nearest the site.   The study’s authors stated, “the impacts are especially pronounced for fetuses exposed in the first trimester, and for male fetuses. We estimate that in this group, exposure to the dust cloud more than doubled the probability of premature delivery and had similarly large effects on the probability of low birth weight.”   This is more evidence that even short term air pollution exposure can affect the developing fetus, and therefore life long health.

Currie J, et al. The 9/11 Dust Cloud and Pregnancy Outcomes: A Reconsideration
The Journal of Human Resources 51(4):805-831, DOI: 10.3368/jhr.51.4.0714-6533R

More research confirming the connection between air pollution and poor birth outcomes.

Balsa UI, et al. Exposures to Particulate Matter from the Eruptions of the Puyehue Volcano and Birth Outcomes in Montevideo. Environ Health Perspect; DOI:10.1289/EHP235

Exposure to NOx pollution had a significant association with the incidence of a serious pregnancy complication, placental abruption.

Michikawa T, et al. Air Pollutant Exposure within a Few Days of Delivery and Placental Abruption in Japan.  Epidemiology. 2016 Dec 1. [Epub ahead of print]

Here is another study showing that air pollution during pregnancy precipitates the chemical markers of inflammation, a prelude to chronic disease vulnerability later in life for those babies.

Martens DS, et al. Neonatal Cord Blood Oxylipins and Exposure to Particulate Matter in the Early-Life Environment: An ENVIRONAGE Birth Cohort Study. Environ Health Perspect. 2016 Nov 4. [Epub ahead of print]

Changes in mitochondrial DNA (mtDNA) can serve as a marker of cumulative oxidative stress.  Increased PM2.5 during the third trimester of pregnancy was associated with decreased mtDNA content suggesting heightened sensitivity to this kind biological damage in a fetus.

Rosa MJ, et al. Identifying sensitive windows for prenatal particulate air pollution exposure and mitochondrial DNA content in cord blood. Environ Int. 2016 Nov 11. pii: S0160-4120(16)30741-3. doi: 10.1016/j.envint.2016.11.007. [Epub ahead of print]

UPHE is adamantly opposed to the proposed project to dam the Bear River, reducing the flow to the Great Salt Lake, shrinking the lake, exposing thousands more acres of dry beach, and increasing the severity of dust storms.  This study shows that dust storms in North America, like other forms of air pollution, increase mortality within a matter of days.

Crooks JL, et al. The Association between Dust Storms and Daily Non-Accidental Mortality in the United States, 1993–2005. Environ Health Perspect; DOI:10.1289/EHP216

Numerous studies solidify the connection between air pollution and diabetes and impaired glucose metabolism.

Peng C, et al. Particulate Air Pollution and Fasting Blood Glucose in Nondiabetic Individuals: Associations and Epigenetic Mediation in the Normative Aging Study, 2000–2011. Environ Health Perspect; DOI:10.1289/EHP183

Lu MC, et al. Association of temporal distribution of fine particulate matter with glucose homeostasis during pregnancy in women of Chiayi City, Taiwan. Environ Res. 2016 Oct 13;152:81-87. doi: 10.1016/j.envres.2016.09.023. [Epub ahead of print

Toledo-Corral CM, et al. Effects of air pollution exposure on glucose metabolism in Los Angeles minority children.  Pediatr Obes. 2016 Dec 6. doi: 10.1111/ijpo.12188. [Epub ahead of print]

Wallwork RS, Colicino E, Zhong J, Kloog I, Coull BA, Vokonas P, Schwartz JD, Baccarelli AA. Ambient Fine Particulate Matter, Outdoor Temperature, and Risk of Metabolic Syndrome. Am J Epidemiol. 2016 Dec 7. [Epub ahead of print]

Ozone was associated with increased rates of hospitalization for dementia in a population in Spain.

Linares C, et al. Short-term association between environmental factors and hospital admissions due to dementia in Madrid. Environ Res. 2016 Oct 27;152:214-220. doi: 10.1016/j.envres.2016.10.020. [Epub ahead of print]

Air pollution’s association with cognitive decline is now well established.  This study shows that among older people who also experience socioeconomic stress and disadvantage, that association is even stronger.

Ailshire J, Karraker A, Clarke P. Neighborhood social stressors, fine particulate matter air pollution, and cognitive function among older U.S. adults. Soc Sci Med. 2016 Nov 14;172:56-63. doi: 10.1016/j.socscimed.2016.11.019. [Epub ahead of print]

More evidence that PM 2.5 air pollution is associated with systemic autoimmune rheumatic diseases (SARDs), as well as an increased relative risk for juvenile idiopathic arthritis

Sun G, et al. Association between Air Pollution and the Development of Rheumatic Disease: A Systematic Review. Int J Rheumatol. 2016;2016:5356307. Epub 2016 Oct 25.

This study shows that ultra fine particulate pollution can affect development of the fetal brain by changing the expression of neuroprotective genes on nerve cells.
Solaimani P, Saffari A, Sioutas C, Bondy SC, Campbell A. Exposure to ambient ultrafine particulate matter alters the expression of genes in primary human neurons. Neurotoxicology. 2016 Nov 13. pii: S0161-813X(16)30225-X. doi: 10.1016/j.neuro.2016.11.001. [Epub ahead of print]

More research showing the connection between environmental factors, air pollution in particular, and autism.   Autism genes are affected by environmental pollutants.

Morales-Suárez-Varela M, et al. Systematic review of the association between particulate matter exposure and autism spectrum disorders. Environ Res. 2016 Dec 13;153:150-160. doi: 10.1016/j.envres.2016.11.022. [Epub ahead of print]
.
Carter CJ, et al. Autism genes are selectively targeted by environmental pollutants including pesticides, heavy metals, bisphenol A, phthalates and many others in food, cosmetics or household products. Neurochem Int. 2016 Oct 27. pii: S0197-0186(16)30197-8. doi: 10.1016/j.neuint.2016.10.011. [Epub ahead of print]

Children exposed to more traffic pollution short term, score worse on tests of ability to pay attention.

Sunyer J, et al. Traffic-related air pollution and attention in primary school children: short-term association.  Epidemiology. 2016 Nov 29. [Epub ahead of print]

Some of the first research showing that air pollution reduces kidney function, even at levels significantly below the national EPA standards.

Raaschou-Nielsen O, et al. Outdoor air pollution and risk for kidney parenchyma cancer in 14 European cohorts. Int J Cancer. 2016 Dec 22. doi: 10.1002/ijc.30587. [Epub ahead of print]

This study shows that for the signature outcome of air pollution exposure, a heart attack, the event is likely to be more immediate in older age groups, and more delayed in younger patients.  Nonetheless, younger patients are still sensitive to the cardiovascular effects of air pollution.

Collart P, et al. Short-term effects of air pollution on hospitalization for acute myocardial infarction: age effect on lag pattern. Int J Environ Health Res. 2017 Feb;27(1):68-81. doi: 10.1080/09603123.2016.1268678.

Another study showing that exposure to particulate matter is associated with the thickness of atherosclerosis in the body’s arteries.

Aguilera I, et al. Particulate Matter and Subclinical Atherosclerosis: Associations between Different Particle Sizes and Sources with Carotid Intima-Media Thickness in the SAPALDIA Study. Environ Health Perspect; DOI:10.1289/EHP161

This is intuitively obvious, but this study shows higher rates of exacerbations of COPD with more air pollution.

Li J, et al. Major air pollutants and risk of COPD exacerbations: a systematic review and meta-analysis.  Int J Chron Obstruct Pulmon Dis. 2016 Dec 12;11:3079-3091. doi: 10.2147/COPD.S122282. eCollection 2016.

leukemia-2

Research paper of the month

Oct. 30, 2016

Air pollution has been classified as a “Class I carcinogen” by the World Health Organization.  There has been a steady increase in the incidence of Acute Myeloid Leukemia (AML) over the past several decades, and other research implicates air pollution as a trigger for leukemia.   This study showed that compared to healthy children, those who had AML had significantly higher levels of “particulate matter derived nanoparticles” aggregated with blood components.  This demonstrates a plausible mechanism by which air pollution could trigger AML.

Visani G, et al. Environmental nanoparticles are significantly over-expressed in acute myeloid leukemia.  Leuk Res. 2016 Nov;50:50-56.

For every 10 ug/m3 of PM2.5, the risk of intrauterine inflammation (IUI) increased 240%.  IUI contributes to, or is a mechanism for, multiple types of pregnancy complications.

Nachman R, et al. Intrauterine Inflammation and Maternal Exposure to Ambient PM2.5 during Preconception and Specific Periods of Pregnancy: The Boston Birth Cohort. Environ Health Perspect; DOI:10.1289/EHP243

This study shows that a 2.1 ug/m3 increase in chronic PM2.5 exposure was associated with a decrease in kidney function equivalent to what would be expected from 2 yrs of aging.  Bear in mind that the Wasatch Front averages a PM2.5 of about 10.  So that would be a decrease in kidney function equivalent to ten years of aging.

Mehta A, et al. Long-Term Exposure to Ambient Fine Particulate Matter and Renal Function in Older Men: The Veterans Administration Normative Aging StudyEnviron Health Perspect. 2016 Sep; 124(9): 1353–1360.

Even one to two day episodes of air pollution may be enough to trigger premature births.

Li S, et al. Acute Impact of Hourly Ambient Air Pollution on Preterm Birth. Environ Health Perspect; DOI:10.1289/EHP200

This is a review article highlighting the evidence that air pollution exposure during pregnancy and even preconception can affect the fetal development of organs like the lungs.

Veras MM, et al. Before the first breath: prenatal exposures to air pollution and lung development.  Cell Tissue Res. 2016 Oct 10. [Epub ahead of print]

More evidence that episodic air pollution, typical of Utah’s inversions, provokes damage to the lining of blood vessels, which can contribute to acceleration of age related vascular disease, and ultimately strokes, heart attacks, sudden death, and poor pregnancy outcomes.  The subjects studied were young healthy adults.

Pope CA, Bhatnagar A, McCracken J, Abplanalp WT, Conklin DJ, O’Toole TE. Exposure to Fine Particulate Air Pollution Is Associated with Endothelial Injury and Systemic Inflammation.  Circ Res. 2016 Oct 25. pii: CIRCRESAHA.116.309279.

Sept. 10, 2016

0905magnetic01

This study documents that toxic, nano-sized particles called “magnetites” found in air pollution end up in our brains. People with higher concentrations of the metallic nanoparticles are known to be at higher risk for Alzheimer’s, and the kind of brain damage these “magnetites” can cause are consistent with the disease.
At 150 nanometers or less in diameter, these particles, including iron oxide, platinum, nickel, and cobalt, whose origin can be industrial, vehicle or other sources of pollution, are small enough to be inhaled through the nose and enter the brain through the olfactory nerve system. The researchers found millions of these particles per gram of brain tissue after studying numerous autopsies. The lead study author said these results are “dreadfully shocking”.

Maher, B, et al. Magnetite pollution nanoparticles in the human brain. PNAS 2016 ; published ahead of print September 6, 2016, doi:10.1073/pnas.1605941113

More evidence that particulate air pollution harms the brain, in this case, decreases cognition in people 50-80 yrs old.

Tzivian L, et al. Long-Term Air Pollution and Traffic Noise Exposures and Mild Cognitive Impairment in Older Adults: A Cross-Sectional Analysis of the Heinz Nixdorf Recall Study. Environ Health Perspect; DOI:10.1289/ehp.1509824

This meta-analysis demonstrated an association between autism NOx and particulate pollution.

Flores-Pajot MC, Ofner M, Do MT, Lavigne E, Villeneuve PJ. Childhood autism spectrum disorders and exposure to nitrogen dioxide, and particulate matter air pollution: A review and meta-analysis.  Environ Res. 2016 Aug 25. pii: S0013-9351(16)30317-6. doi: 10.1016/j.envres.2016.07.030. [Epub ahead of print]

More evidence that air pollution increases the risk for insulin resistance and type II diabetes.

Wolf K, Popp A, Schneider A, Breitner S, Hampel R, Rathmann W, Herder C, Roden M, Koenig W, Meisinger C, Peters A; Association Between Long-Term Exposure to Air Pollution and Biomarkers Related to Insulin Resistance, Subclinical Inflammation and Adipokines. Diabetes. 2016 Sep 7. pii: db151567. [Epub ahead of print]

hith-london-fog-2660357-AB

July 30, 2016

Research paper of the month

This study showed that the Great London Smog event of 1952, was still impacting people’s health 60 years later.  Those who were infants or babies in utero when they were exposed to the event (which only lasted 5 days), showed higher rates of respiratory disease measured several decades later.

Bharadwaj P, et al. Early Life Exposure to the Great Smog of 1952 and the Development of Asthma.  Am J Respir Crit Care Med. First published online 08 Jul 2016 as DOI: 10.1164/rccm.201603-0451OC

We have know for several years that even low levels of particulate pollution (PM2.5) are associated with increased rates of daily death.  Here is more evidence.

Schwartz J. et al. Estimating Causal Effects of Local Air Pollution on Daily Deaths: Effect of Low Levels.  Environ Health Perspect; DOI:10.1289/EHP232

dairy-cow1

It is well established that air pollution increases human mortality. Here is an interesting study that shows air pollution increases mortality in animals, in this case dairy cows.

Cox B, Gasparrini A, Catry B, Fierens F, Vangronsveld J, Nawrot TS. Ambient Air Pollution-Related Mortality in Dairy Cattle: Does It Corroborate Human Findings? Epidemiology. 2016 Jul 27. [Epub ahead of print]

Air pollution accelerates the aging process, at least in part by shortening the length of telomeres. Life expectancy is proportional to telomere length, and the initial length of telomeres at birth is largely the result of environmental factors. Telomeres can be considered the cellular memories of exposure to oxidative stress and inflammation throughout a life time.

Martens DS, Nawrot TS. Air Pollution Stress and the Aging Phenotype: The Telomere Connection. Curr Environ Health Rep. 2016 Jun 29. [Epub ahead of print]

Air pollution is associated with  a loss of the sense of smell (which incidentally is one of the first signs of Alzheimer’s).

Ajmani GS, et al. Effects of Ambient Air Pollution Exposure on Olfaction: A Review.  Environ Health Perspect. 2016 Jun 10. [Epub ahead of print]

Mounting evidence on the connection between type II diabetes and air pollution.

Eze IC, et al. Air pollution and diabetes association: Modification by type 2 diabetes genetic risk score. Environ Int. 2016 Jun 6;94:263-271. doi: 10.1016/j.envint.2016.04.032. [Epub ahead of print]

Goettems-Fiorin PB, et al. Fine particulate matter potentiates type 2 diabetes development in high-fat diet-treated mice: stress response and extracellular to intracellular HSP70 ratio analysis. J Physiol Biochem. 2016 Jun 29. [Epub ahead of print]

Communities with higher air pollution see more prescription use of medications for psychiatric disorders.

Oudin, A., Bråbäck, L., Oudin Åström, D., Strömgren, M., Forsberg, B.: Association between neighbourhood air pollution concentrations and dispensed medication for psychiatric disorders in a large longitudinal cohort of Swedish children and adolescents. BMJ Open 2016;6:e010004 doi:10.1136/bmjopen-2015-010004

More research showing the effect of air pollution on pregnancy and fetal development

Impaired fetal growth, fetal loss, and neonatal deaths were significantly associated with heavy metals exposure during pregnancy.

Rahman A, Kumarathasan P, Gomes J. Infant and mother related outcomes from exposure to metals with endocrine disrupting properties during pregnancy. Sci Total Environ. 2016 Jul 1. pii: S0048-9697(16)31309-2. doi: 10.1016/j.scitotenv.2016.06.134. [Epub ahead of print]

This study demonstrated that the number of blood vessels in the placenta is decreased in the first trimester among women exposed to more NO2.

Hettfleisch K, et al. Short-Term Exposure to Urban Air Pollution and Influences on Placental Vascularization Indexes. Environ Health Perspect. 2016 Jul 6. [Epub ahead of print]

Particulate pollution is associated with higher rates of heart birth defects

Liu CB, et al. Effects of Prenatal PM10 Exposure on Fetal Cardiovascular Malformations in Fuzhou, China: A Retrospective Case-Control Study. Environ Health Perspect. 2016 Jul 6. [Epub ahead of print]

Vanadium is a heavy metal that has been recently recognized as a significant toxin, and is emitted as a byproduct of fossil fuel combustion, especially common in refinery emissions.  The more vanadium in a mother’s body, the higher the rate of low birthweight

Jiang M, et al. A nested case-control study of prenatal vanadium exposure and low birthweight.  Hum Reprod. 2016 Jul 4. pii: dew176. [Epub ahead of print]

More evidence that toxic compounds in air pollution, from traffic and industrial sources, can cause cancer, in this case brain cancer in children with in utero, or infancy exposure.

von Ehrenstein O, et al.  In Utero and Early-Life Exposure to Ambient Air Toxics and Childhood Brain Tumors: A Population-Based Case–Control Study in California, USA Environ Health Perspect; DOI:10.1289/ehp.1408582

Kawasaki Disease is an inflammation of the blood vessels that afflicted infants an young children.  This study showed a statistical association between KD and ozone exposure. Air pollution certainly causes inflammation, so this is not a surprise.

Jung CR, et al.  Ambient Air Pollutant Exposures and Hospitalization for Kawasaki Disease in Taiwan: A Case-Crossover Study (2000-2010)  Environ Health Perspect; DOI:10.1289/EHP137

 

May 28, 2106

This is probably the best study to date showing that air pollution does indeed increase risk for still births.  This meta-analysis showed a 2% increase for every 4 ug/m3 PM2.5. During a bad winter inversion and the height of the Uinta Basin drilling activity, at the one poorly placed monitor in Vernal, there was often PM2.5 of over 60. If that monitor had been placed in downtown Vernal, it would very likely have been much worse.  Winter inversions in the Salt Lake Valley can reach PM2.5 levels of over 90.  NOx, SO2, CO, and ozone were also shown to significantly correlate with still births.   Vernal has had the unique distinction of simultaneously high ozone, and high PM2.5.

Siddika N, Balogun HA, Amegah AK, Jaakkola JJ. Prenatal ambient air pollution exposure and the risk of stillbirth: systematic review and meta-analysis of the empirical evidence. Occup Environ Med. 2016 May 24. pii: oemed-2015-103086. doi: 10.1136/oemed-2015-103086. [Epub ahead of print] Review. 

alberta-tar-sands

The study below showed that the multi-faceted operations of the Canadian Tar Sands are a major source of air pollution in North America.  The authors state this has implications for other sources of “heavy oil” extraction.  That would include the heavy black wax crude in the Uinta Basin.  These two studies certainly reinforce our concern about air pollution as the most likely explanation for the spike in infant deaths in Vernal.

Leggy J, et al. Oil sands operations as a large source of secondary organic aerosols  Nature (2016) doi:10.1038/nature17646

atherosclerosis-31

This is a landmark study showing chronic PM 2.5 levels of as little as 5 ug/m3 correlate with a 20% increase in development of coronary artery calcification over ten years.  The EPA’s annual standard is 12.5 ug.  So based on the metric from this study, what the EPA considers “safe” or acceptable, will increase the “hardening” of your arteries  over 70 yrs, by 360%.  Doesn’t sound very safe does it?

Kaufman, J, et al. Association between air pollution and coronary artery calcification within six metropolitan areas in the USA (the Multi-Ethnic Study of Atherosclerosis and Air Pollution): a longitudinal cohort study.  DOI: http://dx.doi.org/10.1016/S0140-6736(16)00378-0

The risk of a ischemic stroke with air pollution is well established.  This study shows that particulate pollution and ozone are significantly correlated with hemorrhagic stroke as well.

Han M, et al. Association between hemorrhagic stroke occurrence and meteorological factors and pollutants.  BMC Neurol. 2016 May 4;16(1):59. doi: 10.1186/s12883-016-0579-2.

More evidence on the association between air pollution and type II diabetes.  This study is from China, where the air pollution is particularly severe.

Liu C, et al. Associations between long-term exposure to ambient particulate air pollution and type 2 diabetes prevalence, blood glucose and glycosylated hemoglobin levels in China. Environ Int. 2016 May 2;92-93:416-421. doi: 10.1016/j.envint.2016.03.028. [Epub ahead of print]

 

May 1, 2016

Following almost 67,000 people, researchers found there is a strong correlation between chronic exposure to particulate pollution, and death due to all types of cancer. In particular for every 10 ug/m3 of PM2.5 (which is about the annual average for the Wasatch Front), there was an overall increase of 22% in death from cancer, and even higher rates for lung and digestive system cancers, and an extraordinary increase of 80% in death rates for breast cancer, the most common cancer in women. Any of your loved ones have breast cancer? This should make the issue of air quality very personal to everyone.

Wong CM, et al. Cancer Mortality Risks from Long-term Exposure to Ambient Fine Particle.  Cancer Epidemiol Biomarkers Prev; Published OnlineFirst April 29, 2016; doi 10.1158/1055-9965.EPI-15-0626

This will likely be considered a landmark study. It shows that even air quality we label
“good,” or “green”, i.e. PM2.5 of about 10 ug/m3, doubles the incidence of “intrauterine inflammation” which is a strong predisposition for premature birth. Furthermore, it shows that level of pollution even in the first three months prior to conception, increases the risk of intrauterine inflammation 52%.

Nachman RM, et al. Intrauterine Inflammation and Maternal Exposure to Ambient PM2.5 during Preconception and Specific Periods of Pregnancy: The Boston Birth Cohort. Environ Health Perspect. 2016 Apr 27. [Epub ahead of print]

UPHE has been beating the drum on all the medical research showing how toxic air pollution is to the brain.  Here is yet another study showing impairment of cognitive abilities and memory in eight year old school children.

Basagaña X, et al. Neurodevelopmental Deceleration by Urban Fine Particles from Different Emission Sources: A Longitudinal Observational Study. Environ Health Perspect. 2016 Apr 29;124(5). [Epub ahead of print] 

This study shows that hourly levels of air pollution at the time labor begins, show a significant correlation with rates of premature birth.

Li S, Guo Y, Williams G. Acute Impact of Hourly Ambient Air Pollution on Preterm Birth.  Environ Health Perspect. 2016 Apr 29. [Epub ahead of print]

Another study showing air pollution is associated with depression–in this case PM2.5 of 10 ug/m3 associated with about a 50% increase.

Kim KN, et al. Long-Term Fine Particulate Matter Exposure and Major Depressive Disorder in a Community-Based Urban Cohort. Environ Health Perspect. 2016 Apr 29. [Epub ahead of print]

More evidence that short-term exposure to PM2.5  promotes type II diabetes, by inducing vascular insulin resistance and inflammation triggered by a mechanism involving inflammation in the lungs.

Haberzettl P, O’Toole TE, Bhatnagar A, Conklin DJ. Exposure to Fine Particulate Air Pollution Causes Vascular Insulin Resistance by Inducing Pulmonary Oxidative Stress. Environ Health Perspect. 2016 Apr 29. [Epub ahead of print]

Another study showing air pollution changes the placental epigenetic profile, putting a newborn at risk for adverse health outcomes later in life.

Tsamou M, et al. Air pollution-induced placental epigenetic alterations in early life: a candidate miRNA approach. Epigenetics. 2016 Apr 22:0. [Epub ahead of print]

Exposure to traffic related pollution at birth was associated with a 500% increased risk for a certain type of childhood leukemia (AML).

Janitza AE, et al. Traffic-related air pollution and childhood acute leukemia in Oklahoma.  Environmental Research. Volume 148, July 2016, Pages 102–111 

Children exposed to more traffic related air pollution at home, have lower grade point averages, even when other known confounding variables are factored in.

Clark-Reyna SE, et al. Residential exposure to air toxics is linked to lower grade point averages among school children in El Paso, Texas, USA. Popul Environ. 2016 Mar;37(3):319-340. Epub 2015 Jul 17.

Prenatal exposure to NOx is associated with increased risk for childhood obesity

Lavigne E, et al. Air Pollution Exposure During Pregnancy and Fetal Markers of Metabolic Function: The MIREC Study. Am J Epidemiol. 2016 Mar 29. pii: kwv256. [Epub ahead of print]

Measuring PAH (polycyclic aromatic hydrocarbons)/DNA adducts from umbilical cord blood (as an indication of air pollution exposure), there was a significant correlation between prenatal air pollution exposure and anxiety, depression, aggressive behavior, and attention problems in children up to 11 years old.

Margolis AE, et al. Longitudinal effects of prenatal exposure to air pollutants on self-regulatory capacities and social competence. J Child Psychol Psychiatry. 2016 Mar 17. doi: 10.1111/jcpp.12548. [Epub ahead of print]

This study found a 24% increase in type II diabetes per increase in long term exposure to PM2.5 of 3.1 ug/m3 (less than a third of annual average on the Wasatch Front).

Hansen AB, et al. Long-term exposure to fine particulate matter and incidence of diabetes in the Danish Nurse Cohort. Environ Int. 2016 Mar 15;91:243-250. doi: 10.1016/j.envint.2016.02.036. [Epub ahead of print]

Among elderly men, air pollution aggravates cardiovascular risk factors, i.e. increased blood pressure, decreased heart rate variability, worse cholesterol profile, and inflammatory biomarkers.  Those effects were generally more pronounced in men who are already at increased risk of cardiovascular disease

Bind MA, et al. Quantile Regression Analysis of the Distributional Effects of Air Pollution on Blood Pressure, Heart Rate Variability, Blood Lipids, and Biomarkers of Inflammation in Elderly American Men: The Normative Aging Study. Environ Health Perspect. 2016 Mar 11. [Epub ahead of print]

March 12, 2016

Acrolein, one of the most toxic components in wood smoke, causes deterioration of heart muscle function after 3 hr exposure.  Deterioration persisted at least as long as 24 hrs.  This study done in mice.

Thompson LC, et al. Acrolein Inhalation Alters Myocardial Synchrony and Performance at and Below Exposure Concentrations that Cause Ventilatory Responses. Cardiovasc Toxicol. 2016 Feb 19. [Epub ahead of print]

High levels of traffic air pollution are associated with significantly higher rates of brain cancer.

Poulsen AH, et al. Air pollution from traffic and risk for brain tumors: a nationwide study in Denmark. Cancer Causes Control. 2016 Feb 18. [Epub ahead of print]

More evidence of air pollution’s effect on pregnancy.  Primary and secondary particulate matter, NOx, and ozone were all associated with higher incidences of pre-term births.

Laurent O, et al. A Statewide Nested Case-Control Study of Preterm Birth and Air Pollution by Source and Composition: California, 2001-2008. Environ Health Perspect. 2016 Feb 19. [Epub ahead of print]

Habitual incense burning in the home is associated with decreased birth weight and small head circumference in term births.  Boys are affected more than girls.

Chen LY, et al. Incense Burning during Pregnancy and Birth Weight and Head Circumference among Term Births: The Taiwan Birth Cohort Study. Environ Health Perspect. 2016 Mar 11. [Epub ahead of print]

PM2.5, and NOx are associated with higher rates of Low Birth Weight Syndrome.

Coker E, et al. Multi-pollutant exposure profiles associated with term low birth weight in Los Angeles County. Environ Int. 2016 Feb 15;91:1-13. doi: 10.1016/j.envint.2016.02.011. [Epub ahead of print]

March 1, 2016

The evidence for air pollution’s neurotoxicity continues to mount.  For every 3 ug/m3 increase in NO2, considered a marker of traffic pollution, rates of Parkinson’s Disease increased 9%. Wasatch Front averages around 25 ug/m3. This study suggests that Wasatch Front pollution is associated with an increase in Parkinson’s of 72%.

Ritz B, et al. Traffic-Related Air Pollution and Parkinson’s Disease in Denmark: A Case–Control Study. Environ Health Perspect; DOI:10.1289/ehp.1409313

Long term exposure to traffic pollution strongly associated with Alzheimer’s and vascular caused dementia.

Oudin, A, et al. Traffic-Related Air Pollution and Dementia Incidence in Northern Sweden: A Longitudinal Study. Environ Health Perspect; DOI:10.1289/ehp.1408322

manhattan2_0 Air pollution over Manhattan, 1970s.

Feb. 17, 2016

The evidence on how air pollution damages the brain continues to mount.  This study followed almost 100,000 people’s chronic air pollution exposure, and found an extraordinary  211% risk of Alzheimer’s per increase of 10.91 ppb in O3, a 138% risk of increase of AD per increase of 4.34 μg/m3 in PM2.5.  Ozone can reach 70-80 ppb in the summer, and PM2.5 70-90 ug/m3 in the winter.

Jung CR, Lin YT, Hwang BF. Ozone, particulate matter, and newly diagnosed Alzheimer’s disease: a population-based cohort study in Taiwan. J Alzheimers Dis. 2015;44(2):573-84. doi: 10.3233/JAD-140855.

Feb. 12, 2016

This fascinating study demonstrates that the increased mortality affect of air pollution persists for decades.  The air pollution you breathed in the 1970s is still increasing your mortality risk.

Hansell A, et al. Historic air pollution exposure and long-term mortality risks in England and Wales: prospective longitudinal cohort study. Thorax 2015;0:1–9. doi:10.1136/thoraxjnl-2015-207111

The body of research revealing the neurotoxicity of air pollution, especially polycyclic aromatic hydrocarbons (PAHs) continues to grow.  This study in people over 60 yrs. old, showed this correlation between metabolites of PAHs measured in urine and cognitive testing:  a 1% increase in PAHs resulted in approximately a 1.8% poorer performance.

Best EA, Juarez-Colunga E, James K, LeBlanc WG, Serdar B (2016) Biomarkers of Exposure to Polycyclic Aromatic Hydrocarbons and Cognitive Function among Elderly in the United States (National Health and Nutrition Examination Survey: 2001-2002). PLoS ONE 11(2): e0147632. doi:10.1371/journal.pone.0147632

There is a growing body of research showing a significant connection between air pollution and Type II diabetes, i.e. decreased glucose tolerance, and insulin sensitivity.  This study showed short term air pollution has these effects as well as increasing bad cholesterol (LDL) , and decreasing the good cholesterol (HDL).

Chen Z, et al. Ambient Air Pollutants Have Adverse Effects on Insulin and Glucose Homeostasis in Mexican Americans. Diabetes Care. 2016 Feb 11. pii: dc151795. [Epub ahead of print]

Another meta-analysis showing the connection between air pollution and multiple types of adverse pregnancy outcomes.

Lamichhane DK, Leem JH, Lee JY1, Kim HC. A meta-analysis of exposure to particulate matter and adverse birth outcomes. Environ Health Toxicol. 2015 Nov 3;30:e2015011. doi: 10.5620/eht.e2015011. eCollection 2015.

Jan. 17, 2016

A 32 study meta-analysis showing significant association between PM2.5 exposure during the second and third trimesters and lower overall birth weights, and higher rates of babies who qualify as having Low Birth Weight Syndrome. Heavy metals and PAHs likely increase the toxicity of PM2.5 in causing this outcome. The authors state, “These robust results further reveal the toxic effect of PM2.5 exposure during pregnancy on fetal growth. Air pollution is ubiquitous. All pregnant women are exposed to it at some level, and immature fetuses are more susceptible.”

Sun X, Luo X, Zhao C, Zhang B, Tao J, Yang Z, Ma W, Liu T. The associations between birth weight and exposure to fine particulate matter (PM<sub>2.5</sub>) and its chemical constituents during pregnancy: A meta-analysis. Environ Pollut. 2015 Dec 28;211:38-47. doi: 10.1016/j.envpol.2015.12.022. [Epub ahead of print]

More evidence that PM2.5 pollution is associated with increased risk for pre-term birth.

DeFranco E, et al. Exposure to airborne particulate matter during pregnancy is associated with preterm birth: a population-based cohort study. Environ Health. 2016 Jan 15;15(1):6. doi: 10.1186/s12940-016-0094-3.

Even more evidence that air pollution reduces the birth weight of infants. Babies born in Beijing, China during 2008 when significant reductions in pollution were achieved for the Olympics, babies born were larger than those born in the year before and the year after.

Rich D, et al. Differences in Birth Weight Associated with the 2008 Beijing Olympic Air Pollution Reduction: Results from a Natural Experiment. Environ Health Perspect; DOI:10.1289/ehp.1408795

Pregnant mothers exposed to more wood smoke, give birth to children that demonstrate worse neurologic scores including visuo-spatial integration, short-term memory, long-term memory, and fine motor skills when tested at ages 6-7.

Cooper L, Eskenazi B, Romero C, Balmes J, Smith KR. Neurodevelopmental performance among school age children in rural Guatemala is associated with prenatal and postnatal exposure to carbon monoxide, a marker for exposure to woodsmoke. Neurotoxicology. 2012 Mar;33(2):246-54. doi: 10.1016/j.neuro.2011.09.004. Epub 2011 Sep 24.

Air pollution associated with higher rates of heart birth defects.

Girguisa M, et al. Maternal exposure to traffic-related air pollution and birth defects in Massachusetts. Environmental Research. Volume 146, April 2016, Pages 1–9

Numerous studies have shown that air pollution is significantly correlated with rates of Type II diabetes.  This study shows the possible biologic mechanism–increased levels of circulating stress hormones and lipid metabolites with even brief exposure to high levels of ozone.

Miller D, et al. Ozone Exposure Increases Circulating Stress Hormones and Lipid Metabolites in Humans. Am J Respir Crit Care Med. 2016 Jan 8. [Epub ahead of print]

Air pollution exposure during fetal development and infancy can have life long consequences.  This study showed decreased lung function measured at age 16 for those adolescents that were exposed to more air pollution during the first year of life.  Additional pollution exposure after that, caused further reductions in lung function.

Schultz E, et al. “Early-Life Exposure to Traffic-related Air Pollution and Lung Function in Adolescence”, American Journal of Respiratory and Critical Care Medicine, Vol. 193, No. 2 (2016), pp. 171-177.

Chronic exposure to PM2.5 is associated with loss of brain white matter in elderly women.  For every 3.49 ug/m3 PM2.5 annual average, the loss of white matter was about what would be seen from 1-2 years of aging.  With Salt Lake City averaging about 10 ug/m3, that means there is an acceleration of brain aging of 3-6 yrs.

Chen JC, et al. Ambient Air Pollution and Neurotoxicity on Brain Structure: Evidence From Women’s Health Initiative Memory Study. ANN NEUROL 2015;78:466–476 

Dec. 12, 2015

This MIT study is from 2013, and we don’t know how we missed this at the time, but it certainly ramps up the relationship between pollution and mortality.  Epidemiologic evidence indicates that annually, 210,000 people in the US die prematurely due to particulate pollution and ozone.  And the average premature death represents a loss of life  of ten years!

PM2.5 generated from coal and diesel combustion are much more potent triggers of cardiovascular disease than PM2.5 from other sources.

Thurston GD, Burnett RT, Turner MC, Shi Y, Krewski D, Lall R, Ito K, Jerrett M, Gapstur SM, Diver WR, Pope CA 3rd. Ischemic Heart Disease Mortality and Long-Term Exposure to Source-Related Components of U.S. Fine Particle Air Pollution. Environ Health Perspect. 2015 Dec 2. [Epub ahead of print]

More exposure to particulate pollution is associated with higher blood levels of triglycerides and total cholesterol.

Shanley RP, Hayes RB, Cromar KR, Ito K, Gordon T, Ahn J. “Particulate Air Pollution and Clinical Cardiovascular Disease Risk Factors”. Epidemiology. 2015 Nov 24. [Epub ahead of print]

More evidence of the neurotoxicity of air pollution

Costa LG, et al. NEUROTOXICITY OF TRAFFIC-RELATED AIR POLLUTION. Neurotoxicology. 2015 Nov 20. pii: S0161-813X(15)30024-3. doi: 10.1016/j.neuro.2015.11.008. [Epub ahead of print]

Particulate pollution associated with higher rates of hospital admissions for multiple sclerosis.

Laura A,, et al. Effects of particulate matter exposure on multiple sclerosis hospital admission in Lombardy region, Italy. Environ Res. 2015 Nov 25;145:68-73. doi: 10.1016/j.envres.2015.11.017. [Epub ahead of print]

Decreased lung function in children postnatally exposed to pesticides.

Raanan R, Balmes JR, Harley KG, Gunier RB, Magzamen S, Bradman A, Eskenazi B. Decreased lung function in 7-year-old children with early-life organophosphate exposure. Thorax. 2015 Dec 3. pii: thoraxjnl-2014-206622. doi: 10.1136/thoraxjnl-2014-206622. [Epub ahead of print]

Elderly people exposed to more air pollution have impaired heart electrical activity (prolonged QT interval).

Mordukhovich I, Kloog I, Coull B, Koutrakis P, Vokonas P, Schwartz J. Association between Particulate Air Pollution and QT Interval Duration in an Elderly Cohort. Epidemiology. 2015 Nov 24. [Epub ahead of print]

 

Nov. 21, 2015

More evidence that air pollution causes poor pregnancy outcomes, especially pre-term births.

Sun X, et al. The association between fine particulate matter exposure during pregnancy and preterm birth: a meta-analysis. BMC Pregnancy Childbirth. 2015 Nov 18;15(1):300.
.
Zhu X, et al. Maternal exposure to fine particulate matter (PM2.5) and pregnancy outcomes: a meta-analysis.  Environ Sci Pollut Res Int. 2015 Mar;22(5):3383-96. doi: 10.1007/s11356-014-3458-7. Epub 2014 Aug 28.

PM2.5 is associated with increased risk for liver cancer.

Pan W, et al. Fine Particle Pollution, Alanine Transaminase, and Liver Cancer: A Taiwanese Prospective Cohort Study (REVEAL-HBV). J Natl Cancer Inst. 2015 Nov 11;108(3). pii: djv341. doi: 10.1093/jnci/djv341. Print 2015 Mar.

Hazardous air pollutant exposure during prenatal life and early infancy are strongly associated with increased rates of certain types of childhood brain tumors.

von Ehrenstein O, et al. In Utero and Early-Life Exposure to Ambient Air Toxics and Childhood Brain Tumors: A Population-Based Case–Control Study in California, USA. Environ Health Perspect; DOI:10.1289/ehp.1408582

More evidence that pre-natal pollution harms brain function in children.  In this case NOx exposure was calculated at birth, verbal IQ tests were done at age seven.

Porta D, Narduzzi S, Badaloni C, Bucci S, Cesaroni G, Colelli V, Davoli M, Sunyer J, Zirro E, Schwartz J, Forastiere F. Air pollution and cognitive development at age seven in a prospective Italian birth cohort.   Epidemiology. 2015 Sep 30. [Epub ahead of print]

The bulk of the evidence suggests that people benefit from exercise, even during pollution situations.  But what is the threshold at which someone does themselves more harm than good is not known.  Aerobic exercise augments the overall inhaled air pollution dose, potentiates the diffusion of pollutants into circulating blood, augments oxidative stress and inflammation, raises blood pressure, impairs vascular function, and unfavorably affect autonomic balance.

Giorgini P, Rubenfire M, Bard RL, Jackson EA, Ferri C, Brook RD. Air Pollution and Exercise: A REVIEW OF THE CARDIOVASCULAR IMPLICATIONS FOR HEALTH CARE PROFESSIONALS. J Cardiopulm Rehabil Prev. 2015 Sep 16. [Epub ahead of print]

New methodology that solidifies the increase in mortality due to air pollution.

Schwartz J, Austin E, Bind MA, Zanobetti A, Koutrakis P. Estimating Causal Associations of Fine Particles With Daily Deaths in Boston. Am J Epidemiol. 2015 Sep 6. pii: kwv101. [Epub ahead of print]

More research strengthening the connection between air pollution and Alzheimer’s and dementia.  Rates increased about 40% for the most exposed group, compared to the least.

Oudin A, Forsberg B, Nordin Adolfsson A, Lind N, Modig L, Nordin M, Nordin S, Adolfsson R, Nilsson LG.  Traffic-Related Air Pollution and Dementia Incidence in Northern Sweden: A Longitudinal Study.  Environ Health Perspect. 2015 Jul 31. [Epub ahead of print] 

Oct. 15, 2015

Pregnant mothers who live closest to fracking sites were 40% more likely to give birth prematurely than those who live farthest away.  Premature birth predisposes a baby to a lifelong increase in vulnerability to a wide variety of poor health outcomes.

Casey JA, Savitz DA, Rasmussen SG, Ogburn EL, Pollak J, Mercer DG, Schwartz BS. Unconventional Natural Gas Development and Birth Outcomes in Pennsylvania, USA. Epidemiology. 2015 Sep 30. [Epub ahead of print]

Pregnant mothers more exposed to neurotoxins in air pollution, in this case styrene and chromium are more likely to give birth to children who are later diagnosed with autism.  It is unclear, however, whether these chemicals are risk factors themselves or if they are just a reflection of the effect of a much larger mixture of toxic compounds.

Talbott EO, et al. Air toxics and the risk of autism spectrum disorder: the results of a population based case-control study in southwestern Pennsylvania. Environ Health. 2015 Oct 6;14:80. doi: 10.1186/s12940-015-0064-1.

May 21, 2015

Another study showing significantly increased risk for Autism Spectrum Disorder with prenatal, and post natal (up to two years after birth) exposure to PM2.5.

Talbott E, et al.  Fine particulate matter and the risk of autism spectrum disorder.  Environmental Research.  Volume 140, July 2015, Pages 414–420  

May 15, 2015

This paper followed 10 million people, and measured the time to first admission for any of three neurodegenerative diseases–dementia, Alzheimer’s, or Parkinson’s.  They found an 8-15% increase in diagnosis of these disorders per 1 ug/m3 increase in long PM2.5 exposure.  That’s a remarkably strong correlation.

Kioumourtzoglou MA, Schwartz JD, Weisskopf MG, Melly SJ, Wang Y, Dominici F, Zanobetti A. Long-term PM2.5 Exposure and Neurological Hospital Admissions in the Northeastern United States. Environ Health Perspect. 2015 May 15. [Epub ahead of print]

Interesting paper that showed decreased birth weight and smaller head circumference in babies born to white, British mothers exposed to more PM2.5, but not in Pakistani mothers.  In contrast, more PM2.5 exposure increased adiposity of newborns in Pakistani mothers, but not in white British mothers.  Not sure what to make of those findings.

Schembari A, de Hoogh K, Pedersen M, Dadvand P, Martinez D, Hoek G, Petherick ES, Wright J, Nieuwenhuijsen MJ.  Ambient Air Pollution and Newborn Size and Adiposity at Birth: Differences by Maternal Ethnicity (the Born in Bradford Study Cohort).  Environ Health Perspect. 2015 May 15. [Epub ahead of print]

May 2, 2015

In Beijing China, for about one month prior to the 2008 Olympics, many of their coal fired power plants were shut down, and traffic was forcibly reduced about 50%, all in an effort to reduce pollution.  In a study of 84,000 births, mothers in their 8th month of pregnancy in 2008, compared to 2007 and 2009, gave birth to babies about 1% larger.  This then is yet another study showing that air pollution reduces birth weight.  1% doesn’t sound like much per baby, but it becomes a very large public health issue when thousands of babies are affected that way.  Reduced birth weight is associated with an increased risk of numerous lifelong chronic diseases and impaired organ function.

Rich D, et al. Differences in Birth Weight Associated with the 2008 Beijing Olympic Air Pollution Reduction: Results from a Natural Experiment. Environ Health Perspect; DOI:10.1289/ehp.1408795
 

April 23, 2015

There are now several studies linking  air pollution to Type I Diabetes.  Two more have been published in the last two weeks.

Bodin J, Stene LC, Nygaard UC. Can Exposure to Environmental Chemicals Increase the Risk of Diabetes Type 1 Development? Biomed Res Int. 2015;2015:208947. Epub 2015 Mar 26.

Malmqvist E. Maternal exposure to air pollution and type 1 diabetes – Accounting for genetic factors.  Environ Res. 2015 Apr 13;140:268-274. doi: 10.1016/j.envres.2015.03.024. [Epub ahead of print]

More and more studies are showing how toxic air pollution is to the brain.  Previous studies have shown loss of white matter volume in children exposed to air pollution in the womb, and in animals exposed shortly after birth.  The study below, examining adults 60 yrs old and older, shows a loss of total brain volume (an indicator of dementia and brain atrophy) with even small increments of PM2.5.   For every 2 ug/m3 increase in PM2.5, brain volume decreased 0.32% and the odds of covert brain infarcts (mini-strokes) increased 46%.  Given that the EPA has recently lowered the annual PM2.5 standard to 12 ug/m3, that means air quality can meet the national standard, and still be responsible for a 2% decrease in your brain matter, and a 280% increased likelihood of provoking  mini-strokes.

Wilker E, et al. Long-Term Exposure to Fine Particulate Matter, Residential Proximity to Major Roads and Measures of Brain Structure. doi: 10.1161/STROKEAHA.114.008348. Published online before print April 23, 2015,

April 14, 2015

Yet another study showing prenatal air pollution exposure is associated with significantly worse neuropsychological development in children.  For every 1 ug/m3 increase in PM2.5,  motor scores were decreased 1.14 points, and every 1 ug/m3 increase in NO2 was associated with a 0.29 point decrease in mental scores.  The Wasatch Front averages 38-57 ug/m3 for NO2.

Lertxundi A, et al. Exposure to fine particle matter, nitrogen dioxide and benzene during pregnancy and cognitive and psychomotor developments in children at 15months of age. Environ Int. 2015 Apr 10;80:33-40. doi: 10.1016/j.envint.2015.03.007. [Epub ahead of print]

April 5, 2015.

Prenatal exposure to pollution increases newborns’ blood pressure.

van Rossem L, et al. Prenatal Air Pollution Exposure and Newborn Blood Pressure. Environ Health Perspect; DOI:10.1289/ehp.1307419

Pregnant mothers exposed to air pollution demonstrate shortened placental telomeres.  Placental telomeres correlate with newborn’s telomeres and telomeres are highly predictive of life expectancy.  There is wide variability in the length of newborn’s telomeres, and most of that variability is related to environmental exposures.   Bottom line–Maternal exposure to air pollution programs her baby to a shorter life span.

Bijnens E, Zeegers MP, Gielen M, Kicinski M, Hageman GJ, Pachen D, Derom C, Vlietinck R, Nawrot TS. Lower placental telomere length may be attributed to maternal residential traffic exposure; a twin study. Environ Int. 2015 Mar 7;79:1-7. doi: 10.1016/j.envint.2015.02.008. [Epub ahead of print]

PAH exposure during pregnancy decreases levels of BDNF (Brain Derived Neurotrophic Factor), critical to brain development, and whose levels correlate inversely with brain dysfunction.

Tang D, Lee J, Muirhead L, Li TY, Qu L, Yu J, et al. 2014. Molecular and neurodevelopmental benefits to children of closure of a coal burning power plant in China. PLoS One 9:e91966.

March 27, 2015.  This was a big week in air pollution research.

Prenatal exposure to PAH air pollutants (in high concentrations in refinery emissions, cigarette smoke and wood smoke) damages fetal brain development, shrinking the volume of white matter primarily in the left hemisphere measured in early childhood, resulting in impaired cognition, ADHD and hyperactive behavior.

Peterson B, et al. Effects of Prenatal Exposure to Air Pollutants (Polycyclic Aromatic Hydrocarbons) on the Development of Brain White Matter, Cognition, and Behavior in Later Childhood. JAMA Psychiatry. Published online March 25, 2015.doi:10.1001/jamapsychiatry.2015.57

http://www.latimes.com/science/sciencenow/la-sci-sn-air-pollution-baby-brains-20150324-story.html

Large study, examining 350,000 births, at PM2.5  levels of slightly more than 16 ug/m3 in the third trimester, showed 42% increased risk of still births.

DeFranco E, et al. Air Pollution and Stillbirth Risk: Exposure to Airborne Particulate Matter during Pregnancy Is Associated with Fetal Death. PLoS One. 2015 Mar 20;10(3):e0120594. doi: 10.1371/journal.pone.0120594.

Previous studies have shown higher rates of virtually every type of adverse pregnancy outcome with air pollution.  This study of 410, 000 pregnant women showed even higher rates of gestational diabetes  with air pollution–20% increase for every 5 ug/m3 of PM2.5 and 18% increase for every 5 ppb of ozone.

Hu H, Ha S, Henderson BH, Warner TD, Roth J, Kan H, Xu X. Association of Atmospheric Particulate Matter and Ozone with Gestational Diabetes Mellitus. Environ Health Perspect. 2015 Mar 20. [Epub ahead of print]

March 24, 2015

Large meta-analysis of 94 studies showed even short term spikes in ozone, carbon monoxide, SO2, NOx, and PM2.5 are associated with significant increases in rates of strokes.  The greatest association was for the same day of exposure, although PM2.5 showed a lingering affect.

Shah A, et al. Short term exposure to air pollution and stroke: systematic review and meta-analysis. BMJ 2015;350:h1295

lung picture jpeg

March 5, 2105.

From the world’s most prestigious medical journal, the New England Journal of Medicine, a landmark study showing improved air quality pays off with improved lung function and actual growth of lung capacity in children.  This not only improves cardiovascular capability, but is a key factor in avoiding adult onset of lung and heart disease and increasing life expectancy, which is highly correlated with lung function.

Gauderman WJ, et al. Association of Improved Air Quality with Lung Development in Children. N Engl J Med 2015; 372:905-913March 5, 2015DOI: 10.1056/NEJMoa1414123

March 5, 2015.  Another study showing kids exposed to more traffic pollution demonstrate intellectual impairment compared to their non-exposed peers.  In this study, similar to other studies, the cognitive loss was over 4%.

Sunnier J, et al. Association between Traffic-Related Air Pollution in Schools and Cognitive Development in Primary School Children: A Prospective Cohort Study. PLOS medicine. Published: March 3, 2015DOI: 10.1371/journal.pmed.1001792

wood fire JPEG

Feb. 28, 2015.  Even a modest program of curtailing community wood smoke in the San Joaquin Valley resulted in a significant reduction in PM2.5, about 15%, and a similar reduction in hospitalization for ischemic heart disease.  Salt Lake City would undoubtedly have an even greater benefit because the average winter temperature in Salt Lake is about ten degrees colder than the San Joaquin Valley, therefore more wood is being burned.

Yap PS, Garcia C. Effectiveness of Residential Wood-Burning Regulation on Decreasing Particulate Matter Levels and Hospitalizations in the San Joaquin Valley Air Basin. Am J Public Health. 2015 Feb 25:e1-e7. [Epub ahead of print]

Feb. 16, 2015   Another recent study compared daily hospital admissions and death rates related to cardiovascular and pulmonary diseases among two cities in South America where one city’s pollution was predominantly from wood smoke and another was from mobile and typical point sources. Compared to the non-wood burning city, the city with primarily wood smoke experienced an increase of 47% for cardiorespiratory deaths, and an increase of 104% for respiratory hospital admissions for every 10 ug/m3 increase in PM10

Díaz-Robles L, et al. Short Term Health Effects of Particulate Matter: A Comparison between Wood Smoke and Multi-Source Polluted Urban Areas in Chile. Aerosol and Air Quality Research, 15: 306–318, doi:10.4209/aaqr.2013.01.0316

 

Comments are closed