Medical References: Chromosomal Damage/Fetal Development/Fertility

1. Bruner-Tran, KL and KG Osteen. 2010. Developmental exposure to TCDD reduces fertility and negatively affects pregnancy outcomes across multiple generations. Reproductive Toxicology http://dx.doi.org/10.1016/j.reprotox.2010.10.003 

2. Rodríguez-Trigo G, Zock J-P, Pozo-Rodríguez F, Gómez, F, et al. Health Effects in Fishermen 2 Years After Assisting With Oil Spill Clean-up Ann Intern Med October 19, 2010 153:I-28; published ahead of print August 23, 2010. 

3. Perera F, Tang W, Herbstman J. Relation of DNA Methylation of 5-CpG Island of ACSL3 to Transplacental Exposure to Airborne PAH and Childhood Asthma.. PloS ONE. Feb. 16, 2009. 

4. Hansen C, Barnett A, Prichard G. The Effect of Ambient Air Pollution during Early Pregnancy on Fetal Ultrasound Measurements during Mid-Pregnancy. Environ Health Persp Vol. 116, Number 3, March 2008. 

5. Bocskay K, Tang D, Orjuela M, et al. Chromosomal Aberrations in Cord Blood Are Associated with Prenatal Exposure to Carcinogenic Polycyclic Aromatic Hydrocarbons. Cancer Epidem Biomarkers and Prev. Vol. 14, 506-511, Feb 2005 

6. Perera F, Tang D, Tu Y, Biomarkers in Maternal and Newborn Blood Indicate Heightened Fetal Susceptibility to Procarcinogenic DNA Damage. Environ Health Persp Vol 112 Number 10 July 2004 

7. Pilsner JR, Hu H, Ettinger A, Sanchez BN, et al. Influence of prenatal lead exposure on genomic methaylation of cord blood DNA. Environ Health Persp, April 2009 

8. Baccarelli A. Breathe deeply into your genes!: genetic variants and air pollution effects.., Am J Respir Crit Care Med. 2009 Mar 15;179(6):431-2. 

9. Baccarelli A, Wright RO, Bollati V, Tarantini L, Litonjua AA, Suh HH, Zanobetti A, Sparrow D, Vokonas PS, Schwartz J. Rapid DNA methylation changes after exposure to traffic particles. Am J Respir Crit Care Med. 2009 Apr 1;179(7):523-4. 

10. Huang YC, Schmitt M, Yang Z, Que LG, Stewart JC, Frampton MW, Devlin RB. Gene expression profile in circulating mononuclear cells after exposure to ultrafine carbon particles. Inhal Toxicol. 2010 May 27. [Epub ahead of print] 

11. Jedrychowski WA, Perera FP, Maugeri U, Mroz E, Klimaszewska-Rembiasz M, Flak E, Edwards S, Spengler JD. Effect of prenatal exposure to fine particulate matter on ventilatory lung function of preschool children of non-smoking mothers. Paediatr Perinat Epidemiol. 2010 Sep;24(5):492-501. 

12. Thomson E, Kumarathasn P, Calderon-garcidueas L, Vincent R. Air pollution alters brain and pituitary endothelin-1 and inducible nitric oxide synthase gene expressions Environmental Research 2007, vol. 105, no2, pp. 224-233 [10 page(s) (article)] (1 p. 1/2) 

13. Pedersen M, Wichmann J, Autrup H, Dang DA, Decordier I, Hvidberg M, Bossi R, Jakobsen J, Loft S, Knudsen LE. Increased micronuclei and bulky DNA adducts in cord blood after maternal exposures to traffic-related air pollution. Environ Res. 2009 Nov; 109(8):1012-20. Epub 2009 Sep 23. 

14. Herr CE, Dostal M, Ghosh R, Ashwood P, Lipsett M, Pinkerton KE, Sram R, Hertz- Picciotto I. Air pollution exposure during critical time periods in gestation and alterations in cord blood lymphocyte distribution: a cohort of livebirths. Environ Health. 2010 Aug 2;9(1):46. 

15. Gonzalez-Pina, R. et al. (2008) Prenatal exposure to ozone disrupts cerebellar monoamine contents in newborn rats. Neurochem. Res. 33, 912–918 

16. Hoxha M, Dioni L, Bonzini M, et al. Association between leukocyte telomere shortening and exposure to traffic pollution: a cross-sectional study on traffic officers and indoor office workers. Environ Health. 2009; 8: 41. Published online 2009 September 21. doi: 10.1186/1476-069X-8-41 

17. Perera FP 2008. Children Are Likely to Suffer Most from Our Fossil Fuel Addiction. Environ Health Perspect 116:987-990. doi:10.1289/ehp.11173 

18. Rubesa J, Rybara R, Prinosilovaa P, Veznika Z, et al. Genetic polymorphisms influence the susceptibility of men to sperm DNA damage associated with exposure to air pollution. Mutation Research 683 (2010) 9–15. 

19. Rubes J, Selevan S, Evenson D, Zudova D, Vozdova M, Zudova Z, Robbins W, Perreault S. Episodic air pollution is associated with increased DNA fragmentation in human sperm without other changes in semen quality. Human Reproduction Vol.20, No.10 pp. 2776–2783, 2005 doi:10.1093/humrep/dei122. Advance Access publication June 24, 2005. 

20. Zhong Y, Carmella S, Upadhyaya P, Hochalter JB, etal. Immediate Consequences of Cigarette Smoking: Rapid Formation of Polycyclic Aromatic Hydrocarbon Diol Epoxides Chem. Res. Toxicol., Article ASAP DOI: 10.1021/tx100345x Publication Date (Web): December 27, 2010 

21. Topinka J, Rossner P Jr, Milcova A, Schmuczerova J, Svecova V, Sram RJ. DNA Adducts and Oxidative DNA Damage Induced by Organic Extracts From PM2.5 in an Acellular Assay. Toxicol Lett. 2011 Feb 14. [Epub ahead of print] 

(Industrial PM2.5 is more genotoxic and causative of oxidative stress than traffic PM2.5) 

22. Madrigano J, Baccarelli A, Mittleman MA, Wright RO, Sparrow D, Vokonas PS, Tarantini L, and Schwartz J. Prolonged exposure to particulate pollution, genes associated with glutathione pathways, and DNA methylation in a cohort of older men. Environmental Health Perspectives http://dx.doi.org/10.1289/ehp.1002773. 

23. Oh SM, Park YR, Kim HR, Park YJ, Kim MJ, Son BH, Lee MJ, Lee SY, Chung KH. Organic extracts of urban air pollution particulate matter (PM2.5)-induced genotoxicity and oxidative stress in human lung bronchial epithelial cells (BEAS-2B cells). Mutat Res. 2011 Apr 16. [Epub ahead of print] 

24. Han X, Zhou N, Cui Z, Ma M, Li L, Cai M, et al. 2011. Association between Urinary Polycyclic Aromatic Hydrocarbon Metabolites and Sperm DNA Damage: A Population Study in Chongqing, China. Environ Health Perspect 119:652-657. doi:10.1289/ehp. 1002340 

25. Gualtieri M, Ovrevik J, Mollerup S, Asare N, Longhin E, Dahlman HJ, Camatini M, Holme JA. Airborne urban particles (Milan winter-PM2.5) cause mitotic arrest and cell death: Effects on DNA, mitochondria, AhR binding and spindle organization. Mutat Res. 2011 May 30. [Epub ahead of print] 

26. Oya E, Ovrevik J, Arlt VM, Nagy E, Phillips DH, Holme JA. DNA damage and DNA damage response in human bronchial epithelial BEAS-2B cells following exposure to 2- nitrobenzanthrone and 3-nitrobenzanthrone: role in apoptosis. Mutagenesis. 2011 Jun 29. [Epub ahead of print] 

27. Abbas I, Garçon G, Saint-Georges F, Andre V, Gosset P, Billet S, Goff JL, Verdin A, Mulliez P, Sichel F, Shirali P. Polycyclic aromatic hydrocarbons within airborne particulate matter (PM(2.5) ) produced DNA bulky stable adducts in a human lung cell coculture model. J Appl Toxicol. 2011 Sep 13. doi: 10.1002/jat.1722. [Epub ahead of print] 

28. Zhang A, Hu H, Sánchez BN, Ettinger AS, Park SK, Cantonwine D, et al. 2011. Association between Prenatal Lead Exposure and Blood Pressure in Female Offspring. Environ Health Perspect :-. http://dx.doi.org/10.1289/ehp.1103736 

29. Sánchez-Guerra M, Pelallo-Martínez N, Díaz-Barriga F, Rothenberg SJ, Hernández-Cadena L, Faugeron S, Oropeza-Hernández LF, Guaderrama-Díaz M, Quintanilla-Vega B. Environmental polycyclic aromatic hydrocarbon (PAH) exposure and DNA damage in Mexican children. Mutat Res. 2011 Dec 17. [Epub ahead of print] 

30. Bind MA, Baccarelli A, Zanobetti A, Tarantini L, Suh H, Vokonas P, Schwartz J. Air Pollution and Markers of Coagulation, Inflammation, and Endothelial Function: Associations and Epigene-environment Interactions in an Elderly Cohort. Epidemiology. 2012 Jan 10. [Epub ahead of print] 

31. Reddy P, Naidoo RN, Robins TG, Mentz G, Li H, London SJ, Batterman S. GSTM1 and GSTP1 gene variants and the effect of air pollutants on lung function measures in South African children. Am J Ind Med. 2012 Jan 6. doi: 10.1002/ajim.22012. [Epub ahead of print] 

32. Møller P, Folkmann JK, Danielsen PH, Jantzen K, Loft S. Oxidative Stress Generated Damage to DNA by Gastrointestinal Exposure to Insoluble Particles. Curr Mol Med. 2012 Jan 27. [Epub ahead of print] 

33. van den Hooven EH, de Kluizenaar Y, Pierik FH, Hofman A, van Ratingen SW, Zandveld PY, et al. 2012. Chronic Air Pollution Exposure during Pregnancy and Maternal and Fetal C-reactive Protein Levels. The Generation R Study. Environ Health Perspect :-. http://dx.doi.org/10.1289/ehp.1104345 

34. Manikkam M, Guerrero-Bosagna C, Tracey R, Haque MM, Skinner MK (2012) Transgenerational Actions of Environmental Compounds on Reproductive Disease and Identification of Epigenetic Biomarkers of Ancestral Exposures. PLoS ONE 7(2): e31901. doi:10.1371/journal.pone.0031901 

35. Herbstman JB, Tang D, Zhu D, Qu L, Sjödin A, Li Z, et al. 2012. Prenatal Exposure to Polycyclic Aromatic Hydrocarbons, Benzo[a]pyrene–DNA Adducts, and Genomic DNA Methylation in Cord Blood. Environ Health Perspect 120:733-738. http://dx.doi.org/ 10.1289/ehp.1104056 

36. Janssen BG, Munters E, Pieters N, Smeets K, Cox B, Cuypers A, et al. 2012. Placental Mitochondrial DNA Content and Particulate Air Pollution During in Utero Life. Environ Health Perspect :-. http://dx.doi.org/10.1289/ehp.1104458 

37. Huang HB, Lai CH, Chen GW, Lin YY, Jaakkola JJ, Liou SH, Wang SL. Traffic- related air pollution and DNA damage: a longitudinal study in taiwanese traffic conductors. PLoS One. 2012;7(5):e37412. Epub 2012 May 21. 

38. Orjuela M, Liu X, et al. Urinary napthol metabolites and chromosomal aberrations in 5 yr old children. Cancer Epidemiol Biomarkers Prev, May 9, 2012 DOI: 10.1158/1055-9965.EPI-12-0214 

39. Fustinoni S, Rossella F, Polledri E, Bollati V, Campo L, Byun HM, Agnello L, Consonni D, Pesatori AC, Baccarelli A, Bertazzi PA. Global DNA methylation and low- level exposure to benzene. Med Lav. 2012 Mar-Apr;103(2):84-95. 

40. Madrigano J, Baccarelli A, Mittleman MA, Sparrow D, Spiro A 3rd, Vokonas PS, Cantone L, Kubzansky L, Schwartz J.   Air Pollution and DNA Methylation: Interaction by Psychological Factors in the VA Normative Aging Study.  Am J Epidemiol. 2012 Jul 12. [Epub ahead of print] 

41. Hou L, Wang S, Dou C, Zhang X, Yu Y, Zheng Y, Avula U, Hoxha M, Díaz A, McCracken J, Barretta F, Marinelli B, Bertazzi PA, Schwartz J, Baccarelli AA. Air pollution exposure and telomere length in highly exposed subjects in Beijing, China: A repeated-measure study. Environ Int. 2012 Aug 4;48C:71-77. [Epub ahead of print] 

42. Tillett T Potential Mechanism for PM10 Effects on Birth Outcomes: In Utero Exposure Linked to Mitochondrial DNA Damage. Environ Health Perspect 120:a363- a363. http://dx.doi.org/10.1289/ehp.120-a363b 

43. Jedrychowski WA, Perera FP, Spengler JD, Mroz E, Stigter L, Flak E, Majewska R, Klimaszewska-Rembiasz M, Jacek R. Intrauterine exposure to fine particulate matter as a risk factor for increased susceptibility to acute broncho-pulmonary infections in early childhood. Int J Hyg Environ Health. 2013 Jan 16. pii: S1438-4639(12)00150-2. doi: 10.1016/j.ijheh.2012.12.014. [Epub ahead of print] 

44. Jung MH, Kim HR, Park YJ, Park DS, Chung KH, Oh SM.Mutat Res. 2012 Dec 12;749(1-2):39-47. Genotoxic effects and oxidative stress induced by organic extracts of particulate matter(PM 10)collected from a subway tunnel in Seoul, Korea. 

45. Hammond SK, Lurmann F, Shaw GM. The Association of Ambient Air Pollution and Traffic Exposures With Selected Congenital Anomalies in the San Joaquin Valley of California. Am J Epidemiol. 2013 Mar 28. [Epub ahead of print] 

46. Hou L, Zhang X, Dioni L, Barretta F, Dou C, Zheng Y, Hoxha M, Bertazzi PA, Schwartz J, Wu S, Wang S, Baccarelli AA. Inhalable particulate matter and mitochondrial DNA copy number in highly exposed individuals in Beijing, China: a repeated-measure study. Part Fibre Toxicol. 2013 Apr 29;10(1):17. [Epub ahead of print] 

48. Ljubimova JY, Kleinman MT, Karabalin NM, Inoue S, Konda B, Gangalum P, Markman JL, Ljubimov AV, Black KL. Gene expression changes in rat brain after short and long exposures to particulate matter in Los Angeles basin air: Comparison with human brain tumors. Exp Toxicol Pathol. 2013 May 17. pii: S0940-2993(13)00054-7. doi: 10.1016/j.etp.2013.04.002. [Epub ahead of print] 

49. Davis DA, Bortolato M, Godar SC, Sander TK, Iwata N, Pakbin P, Shih JC, Berhane K, McConnell R, Sioutas C, Finch CE, Morgan TE. PLoS One. 2013 May 29;8(5):e64128. doi: 10.1371/journal.pone.0064128. Print 2013. Prenatal exposure to urban air nanoparticles in mice causes altered neuronal differentiation and depression- like responses. 

50. Prasad BS, Vidyullatha P, Venkata RP, Tirumala VG, Varre S, Penagaluru UR, Grover P, Mundluru HP, Penagaluru PR. Evaluation of oxidative stress and DNA damage in traffic policemen exposed to vehicle exhaust. Biomarkers. 2013 Jun 5. [Epub ahead of print] 

51. Janssen BG, Godderis L, Pieters N, Poels K, Kici Ski M, Cuypers A, Fierens F, Penders J, Plusquin M, Gyselaers W, Nawrot TS. Placental DNA hypomethylation in association with particulate air pollution in early life. Part Fibre Toxicol. 2013 Jun 7;10(1):22. [Epub ahead of print] 

52. Koehler C, Thielen S, Ginzkey C, Hackenberg S, Scherzed A, Burghartz M, Paulus M, Hagen R, Kleinsasser NH. Nitrogen dioxide is genotoxic in urban concentrations. Inhal Toxicol. 2013 May 23. [Epub ahead of print] 

53. Slama R, Bottagisi S, Solansky I, Lepeule J, Giorgis-Allemand L, Sram R.  Short-Term Impact of Atmospheric Pollution on Fecundability. Epidemiology. 2013 Sep 18. [Epub ahead of print] 

54. Demarini DM. Genotoxicity biomarkers associated with exposure to traffic and near-road atmospheres: a review. Mutagenesis. 2013 Sep;28(5):485-505. doi: 10.1093/ mutage/get042. 

55. Perera F, et al. Prenatal Exposure to Air Pollution, Maternal Psychological Distress, and Child Behavior. Pediatrics, October 2013, 

56. Demarini DM. Genotoxicity biomarkers associated with exposure to traffic and near-road atmospheres: a review. Mutagenesis. 2013 Sep;28(5):485-505. doi: 10.1093/ mutage/get042. 

57. Bass V, Gordon CJ, Jarema KA, Macphail RC, Cascio WE, Phillips PM, Ledbetter AD, Schladweiler MC, Andrews D, Miller D, Doerfler DL, Kodavanti UP. Ozone Induces Glucose Intolerance and Systemic Metabolic Effects in Young and Aged Brown Norway Rats. Toxicol Appl Pharmacol. 2013 Oct 5. pii: S0041-008X(13)00429-8. doi: 10.1016/ j.taap.2013.09.029. [Epub ahead of print] 

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59. Guo L, Byun HM, Zhong J, Motta V, Barupal J, Zheng Y, Dou C, Zhang F, McCracken JP, Diaz A, Marco SG, Colicino S, Schwartz J, Wang S, Hou L, Baccarelli AA. Effects of short-term exposure to inhalable particulate matter on DNA methylation of tandem repeats. Environ Mol Mutagen. 2014 Jan 17. doi: 10.1002/em.21838. [Epub ahead of print] 

60. Shang Y1, Zhang L1, Jiang Y1, Li Y2, Lu P3. Airborne quinones induce cytotoxicity and DNA damage in human lung epithelial A549 cells: The role of reactive oxygen species. Chemosphere. 2014 Jan 27.pii:S0045-6535(14)00016-2. doi: 10.1016/ j.chemosphere.2013.12.079. [Epub ahead of print] 

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63. Yu-Ting L, Yungling L, Chau-Ren J, et al. Air pollution and limb defects: A matched- pairs case-control study in Taiwan. Environmental Research. Volume 132, July 2014, Pages 273–280 

64. Wick P, Malek A, Manser P, Meili D, Maeder-Althaus X, Diener L, et al. 2010. Barrier capacity of human placenta for nanosized materials. Environ Health Perspect 118:432-436. 

65. Brocato J, Sun H, Shamy M, Kluz T, Alghamdi MA, Khoder MI, Chen LC, Costa M. Particulate matter from Saudi Arabia induces genes involved in inflammation, metabolic syndrome and atherosclerosis. J Toxicol Environ Health A. 2014;77(13):751-66. doi: 10.1080/15287394.2014.892446. 

66. Fossati S, Baccarelli A, Zanobetti A, Hoxha M, Vokonas PS, Wright RO, Schwartz J. Ambient particulate air pollution and microRNAs in elderly men. Epidemiology. 2014 Jan;25(1):68-78. doi: 10.1097/EDE.0000000000000026. 

67. Tao MH, Zhou J, Rialdi AP, Martinez R, Dabek J, Scelo G, Lissowska J, Chen J, Boffetta P.
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69. Sancini G, Farina F, Battaglia C, Cifola I, Mangano E, Mantecca P, Camatini M, Palestini P. Health Risk Assessment for Air Pollutants: Alterations in Lung and Cardiac Gene Expression in Mice Exposed to Milano Winter Fine Particulate Matter (PM2.5). PLoS One. 2014 Oct 8;9(10):e109685. doi: 10.1371/journal.pone.0109685. eCollection 2014. 

70. Neophytou AM, Hart JE, Chang Y, Zhang JJ, Smith TJ, Garshick E, Laden F. Short-term traffic related exposures and biomarkers of nitro-PAH exposure and oxidative DNA damage.  Toxics. 2014 Sep;2(3):377-390. 

71. Farhia A, et al. The possible association between exposure to air pollution and the risk for congenital malformations. Environmental Research, Volume 135, November 2014, Pages 173–180 

72. Morales E, et al. Intrauterine and early postnatal exposure to outdoor air pollution and lung function at preschool age. Thorax, 2014; DOI: 10.1136/thoraxjnl-2014-205413 

73. Bolton JL, Auten RL, Bilbo SD. Prenatal air pollution exposure induces sexually dimorphic fetal programming of metabolic and neuroinflammatory outcomes in adult offspring. Brain Behav Immun. 2014 Mar;37:30-44. doi: 10.1016/j.bbi.2013.10.029. Epub 2013 Nov 1. 

74. Carmona JJ, Sofer T, Hutchinson J, Cantone L, Coull B, Maity A, Vokonas P, Lin X, Schwartz J, Baccarelli AA. Short-term airborne particulate matter exposure alters the epigenetic landscape of human genes associated with the mitogen-activated protein kinase network: a cross-sectional study. Environ Health. 2014 Nov 13;13(1):94. [Epub ahead of print] 

75. Møller P, Danielsen PH, Karottki DG, Jantzen K, Roursgaard M, Klingberg H, Jensen DM, Christophersen DV, Hemmingsen JG, Cao Y, Loft S. Oxidative stress and inflammation generated DNA damage by exposure to air pollution particles. Mutat Res Rev Mutat Res. 2014 October – December;762C:133-166. doi: 10.1016/j.mrrev. 2014.09.001. Epub 2014 Sep 16. 

76. Fan T, Fang SC, Cavallari JM, Barnett IJ, Wang Z, Su L, Byun HM, Lin X, Baccarelli AA, Christiani DC.  Heart rate variability and DNA methylation levels are altered after short-term metal fume exposure among occupational welders: a repeated-measures panel study. BMC Public Health. 2014 Dec 16;14(1):1279. [Epub ahead of print] 

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80. Janssen BG, Byun HM, Gyselaers W, Lefebvre W, Baccarelli AA, Nawrot TS. Placental mitochondrial methylation and exposure to airborne particulate matter in the early life environment: An ENVIRONAGE birth cohort study.  Epigenetics. 2015 May 21:0. [Epub ahead of print] 

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